货号：MABN470

品牌：Merck Millipore

规格：

目录价：￥3990.00

市场价格：￥3391.50

会员价格：￥3192.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Copper ATPase 1 Antibody, clone L60/4 | Cat. No. MABN470 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~170 kDa observed. Five isoforms are known to exist at 165 kDa, 172 kDa, 154 kDa, 54 kDa, and 12 kDa. View All» Immunogen: Linear peptide corresponding to human Copper ATPase 1. View All» Clone: L60/4 View All» Isotype: IgG2bκ View All» Background Information: Encoded by the Mc1 gene, Copper ATPase 1 (a Menke’s disease protein), is a 1,500 amino acid protein, which contains six putative metal-binding motifs at the N-terminus. It is suggested to act as a P-type cation-transporting ATPase. Defects in the Mc1 gene are associated with Menke’s disease, an X-linked disorder which is characterized by improper copper transport, resulting in progressive neurological degeneration and death in early childhood. Copper ATPase 1 is expressed certain organs and cell types, but demonstrates little to know expression in liver. View All» Species Reactivity:

• Human

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Human and Rat. Other homologies: Mouse (85% sequence homology). View All» Application Notes: Immunohistochemistry Analysis: A 1:2,000 dilution of this antibody detected Copper ATPase 1 in human colorectal adenocarcinoma tissue and rat cerebellum tissue.Immunohistochemistry Analysis: A representative lot detected Copper ATPase 1 in rat hippocampus tissue.Western Blot Analysis: A representative lot detected Copper ATPase 1 in adult rat brain membrane tissue lysate and in COS-1 cell lysates transfected with Copper ATPase 1, but demonstrated a loss of signal in COS-1 cell lysates transfected with an empty vector. View All» Control: SK-N-SH cell lysate View All» Quality Assurance: Evaluated by Western Blot in SK-N-SH cell lysate.Western Blot Analysis: 2 µg/mL of this antibody detected Copper ATPase 1 in 10 µg of SK-N-SH cell lysate. View All» Purification Method: Protein G purified View All» Presentation: Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q04656 View All» Entrez Gene Number: NP_000043 View All» Gene Symbol:
  • ATP7A

  • MC1

  • MNK
    View All» Alternate Names:
    • Copper-transporting ATPase 1

    • Copper pump 1

    • Menkes disease-associated protein
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry
        View All» Product Name: Anti-Copper ATPase 1, clone L60/4 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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