货号：MABN466

品牌：Merck Millipore

规格：100Ug

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Ankyrin-G Antibody, clone N106/36 | Cat. No. MABN466 View All» Molecular Weight: 480 kDa calculated View All» Immunogen: Recombinant protein corresponding to human Ankyrin-G. View All» Clone: N106/36 View All» Isotype: IgG1κ View All» Background Information: Ankyrins are a family of spectrin-binding proteins that couple the spectrin/actin cytoskeletal network to the cytoplasmic domains of integral membrane proteins which include channels such as the anion exchanger, voltage-dependent sodium channel, and the Na/K ATPase, as well as neuronal cell adhesion molecules related to L1. In the nervous system, three different ankyrins are known to exist; ankyrinB, ankyrinG, and ankyrinR. All three ankyrins contain an N-terminal membrane binding domain, an internal domain capable of binding spectrin, and a C-terminal regulatory domain which is the target of alternative splicing. AnkyrinB, the predominant neuronal ankyrin includes two isoforms of ~220 kDa and ~440 kDa. The ~220 kDa alternatively spliced isoform is the major form present in the adult brain, while the ~440 kDa form is preferentially expressed in the developing neonatal brain. Three forms of ankyrinG (~190 kDa, ~270 kDa, ~480 kDa) are localized in axonal initial segments and the nodes of Ranvier of myelinated axons where fluxes of action potential occur and ion channels are enriched. Ankyrins comprise ~0.5%-1% of the total membrane protein in the adult vertebrate brain. View All» Species Reactivity: Rat View All» Species Reactivity Note: Demonstrated to react with Rat. Other homologies: Human (92% sequence homology), and Mouse (87% sequence homology). View All» Application Notes: Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected Ankyrin-G in rat cerebral cortex tissue.Immunohistochemistry Analysis: A representative lot detected Ankyrin-G in rat optic nerve tissue.Immunofluorescence Analysis: A representative lot detected Ankyrin-G in adult rat cortex tissue.Immunofluorescence Analysis: A representative lot from an independent laboratory detected Ankyrin-G in a rat model of TLE mEC layer II neurons (Hargus, N. J., et al. (2011). Neurobiol Dis. 41(2):361-376.) View All» Control: Rat hippocampus tissue View All» Quality Assurance: Evaluated by Immunohistochemistry in rat hippocampus tissue.Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected Ankyrin-G in rat hippocampus tissue. View All» Purification Method: Protein G purified View All» Presentation: Purified mouse monoclonal IgG1κ in 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q12955 View All» Entrez Gene Number: NP_066267 View All» Gene Symbol: ANK3 View All» Alternate Names:

• Ankyrin-3

• ANK-3

• Ankyrin-G
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunohistochemistry View All» Product Name: Anti-Ankyrin-G, clone N106/36 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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