货号：MABN42

品牌：Merck Millipore

规格：100Ug

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Neuregulin-1 Antibody, clone D11 | MABN42 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Neuregulin-1 at the extracellular domain. View All» Molecular Weight: ~29 kDa observed. This target has been shown to undergo differential splicing during development into ~30 different isoforms. View All» Epitope: Extracellular domain View All» Immunogen: His-tagged recombinant protein corresponding to mouse Neuregulin-1 at the extracellular domain. View All» Clone: D11 View All» Isotype: IgG1κ View All» Background Information: The group of Neuregulin-1 proteins are cell-cell signaling molecules and are ligands for receptor tyrosine kinases of the ErbB/HER subfamily. Type III NRG1 proteins (also referred to as CRD-NRG1 proteins) play a critical role in neural development, including myelination, motor and sensory neuron survival, and neuromuscular synapse development (Falls, 2003). Defects in animals lacking type III NRGs include retraction of nerve terminals from newly formed synapses, absence of Schwann cells from peripheral nerves, and loss of motor and sensory neurons (Wolpowitz et al., 2000). Available evidence indicates that most Type III NRG1 proteins are synthesized as transmembrane proteins with 2 TM domains, and that proteolytic processing produces a bioactive transmembrane form (NTFm) which serves as a juxtacrine signal (Wang, 2001; Falls, 2003). View All» Species Reactivity: Mouse View All» Species Reactivity Note: Demonstrated to react with mouse. View All» Application Notes: Immunocytochemistry Analysis: A previous lot of this antibody was used successfully by an independent laboratory in IC. (Pirotte, D., et al.) View All» Control: Mouse brain microsomal tissue lysate View All» Quality Assurance: Evaluated by Western Blot in mouse brain microsomal tissue lysate.Western Blot Analysis: 0.25 µg/mL of this antibody detected Neuregulin-1 on 10 µg of mouse brain microsomal tissue lysate. View All» Purification Method: Protein G View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q6DR99 View All» Entrez Gene Number: NP_848706 View All» Gene Symbol:

• GGF

• NDF

• GGF2

• HGL

• MST131

• HRGA

• HRG

• HRG1

• SMDF

• ARIA

• pro-NRG1

• MSTP131

• Pro-NRG1
  View All» Alternate Names:
  • neuregulin 1

  • sensory and motor neuron derived factor

  • neu differentiation factor

  • pro-neuregulin-1, membrane-bound isoform

  • heregulin, alpha (45kD, ERBB2 p185-activator)

  • heregulin, alpha (45kD, ERBB2 p185-activator)

  • glial growth factor
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry
      View All» Product Name: Anti-Neuregulin-1, clone D11 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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