货号：MABN37

品牌：Merck Millipore

规格：100Ug

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Ataxin-1 Antibody, 11NQ, clone N76/8 | MABN37 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~ 85 kDa observed View All» Immunogen: Linear peptide corresponding to mouse Ataxin-1. View All» Clone: N76/8 View All» Isotype: IgG2bκ View All» Background Information: Ataxin-1 is a member of the ATXN1 protein family and contains a single AXH domain. It is a neurodegenerative disorder protein thought to have a role in the metabolism of RNA as it has been shown to localize to the RNA and transcription dependent inclusions within the nucleus. A mutation of Ataxin-1 is the cause of spinocerebellar ataxia type-1 (SCA1), a progressive, neurodegenerative disease that is autosomal dominant and primarily affects the Purjinke cells found in brain stem neuronal populations and the cerebellum. Expression of Ataxin-1 is almost ubiquitous, except in the brain where it is isolated to populations of neurons. View All» Species Reactivity:

• Rat

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with rat. Predicted to react with mouse based on immunogen design. View All» Application Notes: Western Blot Analysis: A previous lot was used by an independent laboratory in rat brain tissue lysate. (James Trimmer, UC Davis/NIH NeuroMab Facility)Immunohistochemistry Analysis: 1:500 dilution from a previous lot detected Ataxin-1 in rat cerebral cortex tissue. View All» Control: Rat hippocampus tissue View All» Quality Assurance: Evaluated by Immunohistochemistry in rat hippocampus tissue.Immunohistochemistry Analysis: 1:500 dilution of this antibody detected Ataxin-1 in rat hippocampus tissue. View All» Purification Method: Protein G View All» Presentation: Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P54254 View All» Entrez Gene Number: NP_033150 View All» Gene Symbol:
  • ATXN1

  • ATX1

  • SCA1
    View All» Alternate Names:
    • ataxin 1

    • Spinocerebellar ataxia type 1 protein

    • spinocerebellar ataxia 1 (olivopontocerebellar ataxia 1, autosomal dominant, ataxin 1)

    • ataxin-1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunohistochemistry View All» UniProt Summary: FUNCTION: May be involved in RNA metabolism.SUBUNIT STRUCTURE: Homooligomer By similarity. Interacts with PQBP1, UBIN and USP7 By similarity. Interacts with ANP32A. Interacts with CIC and ATXN1L. Interacts with ZNF804A (By similarity).SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus. Note: Colocalizes with USP7 in the nucleus (By similarity).TISSUE SPECIFICTY: Widely expressed. In brain, the pattern of distribution is limited to neuron populations.DEVELOPMENTAL STAGE: Transient expression burst in Purkinje cells as the cerebellar cortex becomes functional (postnatal day 14), and in mesenchymal cells of the developing intervertebral disks of the spinal column.DOMAIN: The AXH domain is required for interaction with CIC.PTM: Sumoylation is dependent on nuclear localization and phosphorylation at Ser-751 (By similarity).POLYMORPHISM: The murine poly-Gln region is very limited in comparison to human ATXN1 and is not polymorphic.SEQUENCE SIMILARITIES: Belongs to the ATXN1 family.Contains 1 AXH domain. View All» Product Name: Anti-Ataxin-1, 11NQ, clone N76/8 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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