货号：MABN330

品牌：Merck Millipore

规格：

目录价：￥4439.00

市场价格：￥3773.15

会员价格：￥3551.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Glucagon (non-Oxyntomodulin) Antibody, clone 12D4.14.11 | MABN330 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: 21 kDa calculated View All» Immunogen: Linear peptide corresponding to human Glucagon. View All» Clone: 12D4.14.11 View All» Isotype: IgG3κ View All» Background Information: Glucagon is a hormone that is proteolytically cleaved into at least eight different functional peptides. It is produced by pancreatic cells and it has binding sites in the brain, intestines, and liver, among other tissues. Glucagon is secreted in response to hypoglycemia. Through the combined activation of Gsα- and Gq-coupled transmembrane receptors and their downstream signaling pathways, glucagon stimulates the release of glucose from the liver into the bloodstream. One important mechanism underlying this process is the activation of protein kinase A (PKA). PKA signals result in increased transcription of phosphoenolpyruvate carboxykinase, which encodes the rate-limiting enzyme in the production of glucose from noncarbohydrate substrates. PKA signals may also increase the breakdown of glycogen, and suppress glycolysis. Glucagon may also engage in calcium-dependent signaling via PLC. The importance of glucagon in regulating glucose homeostasis, in conjunction with insulin, is underscored by findings that glucagon and glucagon receptor signaling are disrupted in type II diabetes. View All» Species Reactivity:

• Human

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Human and Rat. View All» Application Notes: Immunofluorescence Analysis: A 1:1,500 dilution from a representative lot detected Glucagon (non-Oxyntomodulin) in alpha cells in the Islets of Langerhans in normal rat pancreas sections.Direct ELISA Analysis: A representative lot detected Glucagon (non-Oxyntomodulin) in direct ELISA.Luminex® Analysis: A representative lot detected Glucagon (non-Oxyntomodulin) in Luminex Assay. View All» Control: Normal rat pancreas tissue View All» Quality Assurance: Evaluated by Immunohistochemistry in normal rat pancreas tissue.Immunohistochemistry Analysis: A 1:2,000 dilution of this antibody detected Glucagon (non-Oxyntomodulin) in normal rat pancreas tissue. View All» Purification Method: Protein G purified View All» Presentation: Purified mouse monoclonal IgG3κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P01275 View All» Entrez Gene Number: NP_002045 View All» Gene Symbol: GCG View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Immunohistochemistry (Paraffin)

  • Immunofluorescence

  • ELISA

  • Multiplexing
    View All» Product Name: Anti-Glucagon (non-Oxyntomodulin), clone 12D4.14.11 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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