货号：MABN32

品牌：Merck Millipore

规格：EA

目录价：￥3588.00

市场价格：￥3049.80

会员价格：￥2870.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-ADAM 22 Antibody, clone N46/30 | MABN32 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes ADAM 22 at the cytoplasmic domain. View All» Molecular Weight: Calculated Mw is ~100 kDa View All» Epitope: Cytoplasmic domain View All» Immunogen: Recombinant protein corresponding to mouse ADAM 22 at the cytoplasmic domain. View All» Clone: N46/30 View All» Isotype: IgG2bκ View All» Background Information: ADAM 22 belongs to the ADAM gene family which have been shown to bind integrin and therefore may have a part in cell to cell or cell to matrix interactions. ADAM 22 is unique in the fact that it is only observed in the nervous system and predominantly in the brain. ADAM 22 is attached by cytoskeletal scaffolds to the postsynaptic density and is a receptor for LGI1. View All» Species Reactivity:

• Rat

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with rat. Predicted to react with mouse based on immunogen design. View All» Application Notes: Immunohistochemistry Analysis: 1:400 dilution of this antibody detected ADAM 22 in rat neurons/myelin in putamen area.Western Blot Analysis: A previous lot of this antibody was used by an independent laboratory to detect ADAM 22 in rat and mouse brain tissue lysate (James Trimmer, UC Davis/NIH NeuroMab Facility).Immunoprecipitation Analysis: A previous lot of this antibody was used by an independent laboratory in IP. (Ogawa, Y., et al. (2010). J Neurosci. 30(3):1038–1048.)Immunofluorescence Analysis: A previous lot of this antibody was used by an independent laboratory in IF. (Ogawa, Y., et al. (2010). J Neurosci. 30(3):1038–1048.) View All» Control: Rat myelinated neurite tissue View All» Quality Assurance: Evaluated by Immunohistochemistry in rat myelinated neurite tissue.Immunohistochemistry Analysis: 1:400 dilution of this antibody detected ADAM 22 in rat myelinated neurite tissue. View All» Purification Method: Protein G Purified View All» Presentation: Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9R1V6 View All» Entrez Gene Number: NP_001007221 View All» Gene Symbol:
  • MDC2

  • ADAM 22

  • ADAM22
    View All» Alternate Names:
    • ADAM metallopeptidase domain 22

    • Metalloproteinase-disintegrin ADAM22-3

    • a disintegrin and metalloproteinase domain 22

    • disintegrin and metalloproteinase domain-containing protein 22

    • Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunohistochemistry

      • Immunoprecipitation

      • Immunofluorescence
        View All» UniProt Summary: FUNCTION: Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation (By similarity). Neuronal receptor for LGI1.SUBUNIT STRUCTURE: Interacts with LGI1. Can bind to LGI4. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICTY: Expressed at high levels in the brain. Strongly expressed in cerebellar granule cells and hippocampus. In spinal cord, expression is restricted to gray matter. PTM: The precursor is cleaved by a furin endopeptidase (By similarity).DISRUPTION PHENOTYPE: Mice display severe ataxia within one week after birth and die before weaning, probably due to convulsions. They display marked hypomyelination of the peripheral nerves. SEQUENCE SIMILARITIES: Contains 1 disintegrin domain.Contains 1 EGF-like domain.Contains 1 peptidase M12B domain. View All» Product Name: Anti-ADAM 22, clone N46/30 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
        © 金山科研平台是专业的授权总代理区域代理经销平台。
        © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
        © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
        © 本文地址：https://16ao.com/thread-133092.htm
        © Merck Millipore代理MABN32 Anti-ADAM 22, clone N46/30，产品报价联系微信jinshanbio