货号：MABF99

品牌：Merck Millipore

规格：100UL

目录价：￥3552.00

市场价格：￥3019.20

会员价格：￥2841.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-DC-SIGN Antibody, clone BMD30 | MABF99 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: 27 kDa calculated View All» Immunogen: Histidine-tagged recombinant protein corresponding to mouse DC-SIGN. View All» Clone: BMD30 View All» Isotype: IgG2aκ View All» Background Information: Dendritic cell-specific ICAM-3-grabbing non-integrin (DC-SIGN) is a C-type lectin and has a high affinity for ICAM3 molecules that plays roles in both cell-cell and host-pathogen interactions. DC-SIGN is a type II membrane protein. It is expressed on dendritic cells and mediates the interaction between dendritic cells and resting T cells. Viruses target DC-SIGN to promote infection and spread to other cells. View All» Species Reactivity: Mouse View All» Species Reactivity Note: Demonstrated to react with Mouse. View All» Control: Mouse spleen tissue View All» Quality Assurance: Evaluated by Immunohistochemistry in mouse spleen tissue.Immunohistochemistry Analysis: A 1:200 dilution of this antibody detected DC-SIGN in mouse spleen tissue. View All» Purification Method: Protein G Purified View All» Presentation: Purified Rat Monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q91ZX1 View All» Entrez Gene Number: NP_573501 View All» Gene Symbol:

• Cd209a

• Cire
  View All» Alternate Names:
  • CD209 antigen-like protein A

  • Dendritic cell-specific ICAM-3-grabbing non-integrin

  • DC-SIGN

  • CD_antigen=CD209
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunohistochemistry View All» UniProt Summary: FUNCITON: Probable pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens.SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein PotentiaTISSUE SPECIFICITY: Predominantly expressed in dendritic cells. Detected at very low levels in lung, spleen, lymph nodes and bone marrow. INDUCTION: Down-regulated upon activation of dendritic cells. SEQUENCE SIMILARITIES: Contains 1 C-type lectin domain.CAUTION: In mouse, 5 genes homologous to human CD209/DC-SIGN and CD209L/DC-SIGNR have been identified. Mouse CD209A product was named DC-SIGN by Ref.1 because of its similar expression pattern and chromosomal location in juxtaposition to CD23, but despite of the low sequence similarity. View All» Product Name: Anti-DC-SIGN, clone BMD30 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Rat View All»
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