货号：MABF33

品牌：Merck Millipore

规格：100Ug

目录价：￥4438.00

市场价格：￥3772.30

会员价格：￥3550.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MHC class II (I-A/I-E) Antibody, clone M5/114 | MABF33 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~32 kDa observed. There are 2 isoforms produced by alternative splicing: 32 kDa Isoform Long and 24 kDa Isoform Short. View All» Immunogen: B6 Anti-BNL4Φ lymphocytes View All» Clone: M5/114 View All» Isotype: IgG2bκ View All» Background Information: MHC class II-associated invariant chain (I-A/I-E), also known as Ia antigen-associated invariant chain, are single-pass type II membrane glycoproteins containing a single thyroglobulin type-I domain. They are critical components in the processing of MHC class II antigen through forming a stabilizing complex following the alpha/beta heterodimer synthesis, and orchestrating complex trafficking away from the ER compartments in which class II peptide loading occurs. View All» Species Reactivity: Mouse View All» Species Reactivity Note: Demonstrated to react with mouse. View All» Application Notes: Flow Cytometry Analysis: A previous lot was used by an independent laboratory in FC on spleen cells. (Bhattacharya, A., et al. (1981). The Journal of immunology. 127(6):2488-2496.)Immunohistochemistry Analysis: A previous lot was used by an independent laboratory in IH on thymus tissue. (de Bont, E., et al. (1999). Int. Immunol. 11(8):1295-1306.) View All» Control: Mouse spleen tissue lysate View All» Quality Assurance: Evaluated by Western Blot in mouse spleen tissue lysate.Western Blot Analysis: 1 µg/mL of this antibody detected MHC class II (I-A/I-E) in 10 µg of mouse spleen tissue lysate. View All» Purification Method: Protein G Purified View All» Presentation: Purified rat monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P04441 View All» Entrez Gene Number: NP_001036070 View All» Gene Symbol:

• Ia-GAMMA

• DHLAG

• CD74

• p33

• HLADG

• ii

• Ii
  View All» Alternate Names:
  • CD74 molecule, major histocompatibility complex, class II invariant chain

  • Ia-associated invariant chain

  • CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)

  • gamma chain of class II antigens

  • Ia antigen-associated invariant chain

  • MHC HLA-DR gamma chain

  • HLA class II histocompatibility antigen gamma chain

  • HLA-DR antigens-associated invariant chain

  • HLA-DR-gamma

  • CD74 antigen
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Flow Cytometry

    • Immunohistochemistry
      View All» UniProt Summary: FUNCTION: Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place.SUBUNIT STRUCTURE: Nonamer composed of three alpha/beta/gamma heterotrimers (By similarity).SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein (Potential). SEQUENCE SIMILARITIES: Contains 1 thyroglobulin type-1 domain. View All» Product Name: Anti-MHC class II (I-A/I-E), clone M5/114 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rat View All»
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      © Merck Millipore代理MABF33 Anti-MHC class II (I-A/I-E) Antibody, clone M5/114;store at +2℃ to +8℃，产品报价联系微信jinshanbio