货号：MABF12

品牌：Merck Millipore

规格：100Ug

目录价：￥3574.00

市场价格：￥3037.90

会员价格：￥2859.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Interleukin-17 (IL-17) Antibody, clone 1C12 | MABF12 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~15 kDa observed View All» Immunogen: Cohesin-tagged recombinant protein corresponding to human IL-17. View All» Clone: AB44.57.27E4.1C12 View All» Isotype: IgG2aκ View All» Background Information: Interleukin-17 (IL-17) is known to stimulate the transcription factor nuclear factor (NF)-kappaB and c-Jun NH(2)-terminal kinase. TRAF6 is essential in the IL-17 signaling pathway of proinflammatory response. Over-expression of IL-17 by T cells seems to be important in systemic sclerosis pathogenesis. IL-17 is particularly involved in early development of the disease by activating fibroblast propagation and creation of IL-1. IL-17 connects lymphoid and myeloid host defenses and so plays an essential part in the microbial defense response. IL-17 also seems to support the innate immune response by mobilizing neutrophils. IL-17 may be an important clinical target for allergic airway disease. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Application Notes: ELISA Analysis: A previous lot was used by an independent laboratory in ELISA (Dr. Gerard Zurawski, Baylor Institute for Immunology Research, Dallas, TX). View All» Control: Human IL-17 recombinant protein. View All» Quality Assurance: Evaluated by Western Blot in lysate from cells expressing human IL-17 recombinant protein.Western Blot Analysis: 0.5 µg/mL of this antibody detected 10 µg of human IL-17 recombinant protein. View All» Purification Method: Protein G Purified View All» Presentation: Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q16552 View All» Entrez Gene Number: NP_002181 View All» Gene Symbol:

• IL17A

• CTLA8

• IL-17

• IL17

• IL-17A

• CTLA-8
  View All» Alternate Names:
  • interleukin 17A

  • interleukin-17A

  • interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)

  • cytotoxic T-lymphocyte-associated serine esterase 8

  • Cytotoxic T-lymphocyte-associated antigen 8

  • cytotoxic T-lymphocyte-associated protein 8
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of the intracellular adhesion molecule-1 (ICAM-1) in fibroblasts.SUBUNIT STRUCTURE: Homodimer.SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Restricted to activated memory T-cells.PTM: Found both in glycosylated and nonglycosylated forms.SEQUENCE SIMILARITIES: Belongs to the IL-17 family. View All» Product Name: Anti-Interleukin-17 (IL-17), clone 1C12 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
    © 金山科研平台是专业的授权总代理区域代理经销平台。
    © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
    © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
    © 本文地址：https://16ao.com/thread-133014.htm
    © Merck Millipore代理MABF12 Anti-Interleukin-17 (IL-17) Antibody, clone 1C12;store at +2℃ to +8℃，产品报价联系微信jinshanbio