货号：MABF118

品牌：Merck Millipore

规格：100Ug

目录价：￥3623.00

市场价格：￥3079.55

会员价格：￥2898.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-sTRAIL Antibody, clone III6F | MABF118 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: 33 kDa calculated View All» Immunogen: Human soluble TRAIL View All» Clone: III6F View All» Isotype: IgG2bκ View All» Background Information: TNF-related apoptosis-inducing ligand (sTRAIL or Apo-2L) is the endogenous ligand for the ubiquitous pro-apoptotic TRAIL-R1 and TRAIL-R2 receptors. Upon ligand binding, TRAIL receptors form trimeric structures at the plasma membrane around a central zinc atom. The trimeric TRAIL receptors bind the FADD adaptor protein which in turn recruits caspase 8. TRAIL/APO-2L signals ultimately converge on caspase 3 and related proteins that promote cell death. Importantly, activated TRAIL receptors work cooperatively with death receptors 4 and 5 in transformed cells to induce caspase signaling, thereby preventing the proliferation of abnormal cells. TRAIL/ApO-2L has been implicated in pathophysiology of many disease processes, including cancer and autoimmune diseases. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. View All» Application Notes: Immunohistochemistry Analysis: A representative lot from an independent laboratory detected sTRAIL in frozen sections from human tonsils, lymph nodes and appendix (Liabakk, N. B., et al. (2002). J Immunol Methods. 259(1-2):119-128.).Flow Cytometry Analysis: A representative lot from an independent laboratory detected sTRAIL in REH cells (Liabakk, N. B., et al. (2002). J Immunol Methods. 259(1-2):119-128.). View All» Control: HeLa cells View All» Quality Assurance: Evaluated by Flow Cytometry in HeLa cells.Flow Cytometry Analysis: 2.5 µg/mL of this antibody detected sTRAIL in 2X10E5 HeLa cells. View All» Purification Method: Protein G purified View All» Presentation: Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P50591 View All» Entrez Gene Number: NP_003801 View All» Gene Symbol:

• TNFSF10

• APO2L

• TRAIL
  View All» Alternate Names:
  • Tumor necrosis factor ligand superfamily member 10

  • Apo-2 ligand

  • Apo-2L

  • TNF-related apoptosis-inducing ligand

  • Protein TRAIL

  • CD253
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Flow Cytometry

    • Immunohistochemistry

    • Immunoprecipitation
      View All» Entrez Gene Summary: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. View All» UniProt Summary: FUNCTION: Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.COFACTOR: Binds 1 zinc ion per trimer.SUBUNIT STRUCTURE: Homotrimer.SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.TISSUE SPECIFICITY: Widespread; most predominant in spleen, lung and prostate.SEQUENCE SIMILARITIES: Belongs to the tumor necrosis factor family. View All» Product Name: Anti-sTRAIL, clone III6F View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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