货号：MABE90

品牌：Merck Millipore

规格：

目录价：￥4264.00

市场价格：￥3624.40

会员价格：￥3411.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-ASF1a Antibody, clone MPH7 | MABE90 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes ASF1a, but not ASF1b (Ambagala, A.P., et al. (2009). J Virol. 83(1):200-209.) View All» Molecular Weight: ~23 kDa observed View All» Immunogen: GST tagged recombinant protein corresponding to human ASF1a. View All» Clone: MPH7 View All» Isotype: IgG2bκ View All» Background Information: ASF1a (anti-silencing function 1a) is a histone H3/H4 chaperone and chromatin regulator. This protein facilitates histone placement, removal and exchange during nucleosome assembly/disassembly and is essential for the formation of senescence-associated heterochromatic foci (SAHF). ASF1a interacts with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication independent chromatin assembly. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. View All» Application Notes: This antibody is not recommended for western blotting. View All» Control: Jurkat cell lysate View All» Quality Assurance: Evaluated by Immunoprecipitation in Jurkat cell lysate.Immunoprecipitation Analysis: 10 µg of this antibody immunoprecipitated ASF1a from 100 µg of Jurkat cell lysate. View All» Purification Method: Protein G purified View All» Presentation: Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9Y294 View All» Entrez Gene Number: NP_054753 View All» Gene Symbol:

• ASF1A

• CGI-98

• HSPC146
  View All» Alternate Names:
  • Histone chaperone ASF1A

  • Anti-silencing function protein 1 homolog A

  • hAsf1

  • Asf1a

  • CCG1-interacting factor A

  • CIA

  • hCIA
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunoprecipitation View All» Entrez Gene Summary: This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair. View All» UniProt Summary: FUNCTION: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.SUBUNIT STRUCTURE: Interacts with histone H3 (including both histone H3.1 and H3.3) and histone H4. Interacts with the CHAF1A, CHAF1B and RBBP4 subunits of the CAF-1 complex. Interacts with CABIN1, HAT1, HIRA, NASP, TAF1, TLK1, TLK2 and UBN1.SUBCELLULAR LOCATION: Nucleus. View All» Product Name: Anti-ASF1a, clone MPH7 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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