货号：MABE65

品牌：Merck Millipore

规格：

目录价：￥3433.00

市场价格：￥2918.05

会员价格：￥2746.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Tristetraprolin (TTP), clone 1-3 View All» Promotional Text: Special Offer on Antibodies! Click Here! View All» Molecular Weight: ~30 kDa observed. The calculated molecular weight is 34 kDa; however, this protein has been observed at ~30-40 kDa, and even ~45-50 kDa when phosphorylated (Cao, H., et al. (2004). Biochemistry. 43(43):13724-13738.). View All» Immunogen: Recombinant protein corresponding to the human Tristetraprolin (TTP). View All» Clone: hTTP-214 View All» Isotype: IgG₁ View All» Background Information: TTP (Tristetraprolin, Nup 475, TIS11, G0S24, or ZFP36) is a member of the CCCH tandem zinc finger protein family. It is a nuclear RNA-binding protein that functions as a trans-acting factor. It is involved in post-transcriptional regulation of cytokine genes, most notably Tumor Necrosis Factor alpha (TNF-α). Upon activation by lipopolysaccharides, TTP binds TNF-α mRNA at AU-rich domains in the 3'-untranslated Region (3'-UTR) and induces deadenylation, thereby destabilizing the mRNA and tagging it for degradation. To produce this effect, TTP recruits other trans-acting factors to its C-terminal domain and mRNA-decay enzymes to its N-terminal domain. TTP is deactivated by phosphorylation driven by mitogen-activated protein kinase-activated protein kinase 2 (MK2) and p53. Therefore, TTP/MK2 regulates the biosynthesis of TNF-α and mediates inflammatory responses involving TNF-α. Knockout of TTP in mice produces arthritis, alopecia, dermatitis, among a range of other phenotypes related to overexpression of TNF-α. View All» Species Reactivity: Human View All» Application Notes: Western Blotting Analysis: A representative lot detected Tristetraprolin (TTP) in human lymph node and small intestine tissue. View All» Control: Human thymus tissue lysate View All» Quality Assurance: Evaluated by Western Blotting in human thymus tissue lysate.Western Blotting Analysis: A 1:2,000 dilution of this antibody detected Tristetraprolin (TTP) in 10 µg of human thymus tissue lysate. View All» Purification Method: Protein A purified View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P26651 View All» Entrez Gene Number: NP_003398 View All» Gene Symbol:

• TTP

• G0S24

• RNF162A

• TIS11

• NUP475

• zfp-36

• GOS24

• TIS11A

• tristetraprolin

• Zfp-36
  View All» Alternate Names:
  • zinc finger protein 36, C3H type, homolog (mouse)

  • Growth factor-inducible nuclear protein NUP475

  • Zinc finger protein 36 homolog

  • G0/G1 switch regulatory protein 24

  • zinc finger protein, C3H type, 36 homolog (mouse)

  • zinc finger protein, C3H type, 36 homolog

  • Protein TIS11A
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. Acts by specifically binding ARE-containing mRNAs and promoting their degradation. Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF).SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note: Localizes to stress granules upon energy starvation. phosphorylation by MAPKAPK2 promotes exclusion from stress granules. INDUCTION: By stimulation with various mitogens.PTM: Phosphorylation by MAPKAPK2 increases its stability and binding to 14-3-3 proteins, leading to reduce its ARE affinity leading to inhibition of degradation of ARE-containing transcripts. Phosphorylated upon mitogen stimulation. SEQUENCE SIMILARITIES: Contains 2 C3H1-type zinc fingers. View All» Product Name: Anti-Tristetraprolin (TTP), clone 1-3 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Host: Mouse View All»
    © 金山科研平台是专业的授权总代理区域代理经销平台。
    © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
    © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
    © 本文地址：https://16ao.com/thread-132994.htm
    © Merck Millipore代理MABE65 Anti-Tristetraprol (TTP), clone hTTP-214，产品报价联系微信jinshanbio