货号：MABE348

品牌：Merck Millipore

规格：100UL

目录价：￥5359.00

市场价格：￥4555.15

会员价格：￥4287.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-RNAPII Antibody (Thr4), clone 1G7 | Cat. No. MABE348 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes RNAPII phosphorylated at Thr4. View All» Molecular Weight: ~220 kDa observed View All» Epitope: Phosphorylated Thr4 View All» Immunogen: Ovalbumin-conjugated linear peptide corresponding to human RNAPII phosphorylated at Thr4. View All» Clone: 1G7 View All» Isotype: IgG2aκ View All» Background Information: RNA polymerase II (RNAPII or Pol II) is a multi-subunit enzyme responsible for the transcription of transcription of DNA into RNA from protein-coding genes. Transcription initiation requires recruitment of the complete transcription machinery to a promoter via solicitation by activators and chromatin remodeling factors. RNAPII can coordinate 10 to 14 subunits. This complex interacts with the promoter regions of genes and a variety of elements and transcription factors. The DNA binding domain of the polymerase is a groove where TFIIB orients the DNA for unwinding and transcription. View All» Species Reactivity:

• Human

• Mouse

• Yeast
  View All» Application Notes: Immunoprecipitation Analysis: A representative lot from an independent laboratory detected phospho-RNAPII (Thr4) in HeLa cell extracts (Hintermair, C., et al. (2012). EMBO J. 31(12):2784-2791.).Immunofluorescence Analysis: A representative lot from an independent laboratory detected phospho-RNAPII (Thr4) in HeLa cells (Hintermair, C., et al. (2012). EMBO J. 31(12):2784-2791.).Chromatin Immunoprecipitation (ChIP) Analysis: A representative lot from an independent laboratory immunoprecipitated phospho-RNAPII (Thr4) in stably transfected Raji cell lysates (Hintermair, C., et al. (2012). EMBO J. 31(12):2784-2791.). View All» Control: Untreated and lambda phosphatase treated HeLa cell lysates. View All» Quality Assurance: Evaluated by Western Blot in untreated and lambda phosphatase treated HeLa cell lysates.Western Blot Analysis: A 1:500 dilution of this antibody detected phospho-RNAPII (Thr4) in 10 µg of untreated HeLa cell lysate. (Lambda phosphatase treatment was performed during the western blot procedure.) View All» Purification Method: Protein G purified View All» Presentation: Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P24928 View All» Entrez Gene Number: NP_000928 View All» Gene Symbol:
  • POLR2A

  • POLR2
    View All» Alternate Names:
    • DNA-directed RNA polymerase II subunit RPB1

    • RNA polymerase II subunit B1

    • DNA-directed RNA polymerase II subunit A

    • DNA-directed RNA polymerase III largest subunit

    • RNA-directed RNA polymerase II subunit RPB1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunoprecipitation

      • Immunocytochemistry
        View All» Product Name: Anti-phospho-RNAPII (Thr4), clone 1G7 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Rat View All»
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