货号：MABE320

品牌：Merck Millipore

规格：100Ug

目录价：￥4899.00

市场价格：￥4164.15

会员价格：￥3919.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-c-ErbB2/c-Neu (Ab-5) Antibody, clone TA-1 | MABE320 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the extracellular domain of ErbB2/c-Neu. View All» Molecular Weight: 138 kDa calculated View All» Epitope: Extracellular domain View All» Immunogen: Cells overexpressing human c-ErbB2/c-Neu View All» Clone: TA-1 View All» Isotype: IgG1κ View All» Background Information: The ErbB2 (HER2, c-Neu, ErbB2, c-erbB2, or HER2/neu) protein is member of the human epidermal growth factor receptor (HER) family. It is a receptor tyrosine kinase containing an intracellular kinase domain and an extracellular ligand domain, although no endogenous ligand has yet been found. ErbB2 dimerizes with ErbB1, 3, and 4, and can activate different pathways including the PI3K, PLCγ, and MAPK pathways, depending on the ErbB receptor involved. Coupling with ErbB3 activates the PI3K pathway, whereas coupling with any of these three receptors can induce the MAPK pathway. ErbB2 signaling promotes cell proliferation and inhibits apoptosis. ErbB2 is overexpressed in various cancers and may play a role in the development and metastasis of gliomas, and ovarian, breast, lung, and gastric cancer. View All» Species Reactivity: Human View All» Application Notes: Flow Cytometry Analysis: A representative lot from an independent laboratory detected c-ErbB2/c-Neu in HER-2 expressing SK-BR-3 cells (Montgomery, R. B., et al. (2005). Cancer Res. 65(2):650-656.).Western Blot Analysis: A representative lot from an independent laboratory detected c-ErbB2/c-Neu in HER-2 expressing SK-BR-3 cells (Montgomery, R. B., et al. (2005). Cancer Res. 65(2):650-656.).Immunoprecipitation Analysis: A representative lot from an independent laboratory precipitated c-ErbB2/c-Neu in IP (McKenzie, S. J., et al. (1989). 4(5):543-548.).Immunofluorescence Analysis: A representative lot from an independent laboratory detected c-ErbB2/c-Neu in IF (McKenzie, S. J., et al. (1989). 4(5):543-548.). View All» Control: SK-BR-3 cells View All» Quality Assurance: Evaluated by Flow Cytometry in SK-BR-3 cells.Flow Cytometry Analysis: 0.5 µg of this antibody detected c-ErbB2/c-Neu in 0.5X10E6 SK-BR-3 cells. View All» Purification Method: Protein G purified View All» Presentation: Purified mouse monoclonal IgG1κ cultured supernatent in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P04626 View All» Entrez Gene Number: NP_001005862 View All» Gene Symbol:

• ERBB2

• HER2

• MLN19

• NEU

• NGL
  View All» Alternate Names:
  • Receptor tyrosine-protein kinase erbB-2

  • Metastatic lymph node gene 19 protein

  • MLN 19

  • Proto-oncogene Neu

  • Proto-oncogene c-ErbB-2

  • Tyrosine kinase-type cell surface receptor HER2

  • p185erbB2

  • CD340
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Flow Cytometry

    • Immunoprecipitation

    • Immunofluorescence
      View All» Product Name: Anti-c-ErbB2/c-Neu (Ab-5), clone TA-1 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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