货号：MABE283

品牌：Merck Millipore

规格：100Ug

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-p53 Antibody, clone PAb421 | MABE283 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes amino acids 376-378 of human p53. View All» Molecular Weight: ~53 kDa observed View All» Epitope: Amino acids 376-378 in human p53 View All» Immunogen: Partially purified mouse p53 View All» Clone: PAb421 View All» Isotype: IgG2aκ View All» Background Information: p53 was discovered in 1979 as a cellular protein associating with the transforming protein of SV40 tumor virus. Since then, many different biochemical functions have been attributed to the 53 kDa phosphoprotein. Experimental evidence has suggested that p53 acts as a negative regulator of cell growth in normal cells). Thus, the inactivation or mutation of p53 may be an essential step in the development of malignancy. Wild-type p53 levels in normal cells and tissues were found to be very low. Mutant p53 polypeptide, however, is often found to be present at high concentrations in mammalian tumors and tumor cell lines. For example, in an immuno-histochemistry study 40% of human breast cancer showed elevated levels of mutant p53 in the cell nucleus. Mutations of the p53 protein have some characteristic features: Most of them are missense point mutations giving rise to an altered protein function. Also, many, but not all, mutant p53 proteins exhibit a common mutant structure, which can be recognized by monoclonal antibodies specific for p53 in the mutant conformation. View All» Species Reactivity: Mouse View All» Species Reactivity Note: Demonstrated to react with Mouse. Demonstrated to react with Human. View All» Application Notes: Immunoprecipitation Analysis: A representative lot from independent laboratory immunoprecipitated p53 in IP (Lehman, T. A., et al. (1991). Cancer Res. 51(15):4090-4096.; Harlow, E., et al. (1981). J Virol. 39(3):861-869.)Immunohistochemistry Analysis: A representative lot from an independent laboratory detected p53 in human breast cancer tissue (Davidoff, A. M., et al. (1992). Proc Natl Acad Sci USA. 89(8):3439-3442.). View All» Control: Mouse brain tissue lysate View All» Quality Assurance: Evaluated by Western Blot in mouse brain tissue lysate.Western Blot Analysis: 1 µg/mL of this antibody detected p53 in 10 µg of mouse brain tissue lysate. View All» Purification Method: Protein G purified View All» Presentation: Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt.Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: P02340 View All» Entrez Gene Number: NP_001120705 View All» Gene Symbol:

• Tp53

• P53

• Trp53
  View All» Alternate Names:
  • Cellular tumor antigen p53

  • Tumor suppressor p53
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunoprecipitation

    • Immunohistochemistry
      View All» Product Name: Anti-p53, clone PAb421 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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