货号：MABE269

品牌：Merck Millipore

规格：

目录价：￥3945.00

市场价格：￥3353.25

会员价格：￥3156.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Musashi-2 Antibody | MABE269 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~38 kDa observed. Uniprot describes two other isoforms at ~28 kDa and ~17 kDa. View All» Immunogen: GST tagged recombinant protein corresponding to human Musashi-2. View All» Clone: 6E7.2 View All» Isotype: IgG1κ View All» Background Information: Musashi-2 (Musashi homolog 2; Msi2) is a member of the Musashi family of RNA-binding proteins that binds to mRNA sequences via their RNA-binding motifs. It is highly expressed in mammalian neural precursor cells and is involved in the post-transcriptional regulation of genes affecting CNS development. Musashi-2 is also expressed in subpopulations of neural cells in the mature CNS. Previous studies have demonstrated that the expression of Musashi-2 increases several days after brain injury. Other studies have suggested that Musashi-2 may also play a role in the pathogenesis of myeloid leukemia. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Human, Mouse, and Rat. View All» Application Notes: Western Blot Analysis: 1 µg/mL from a representative lot detected Musashi-2 in 10 µg of T47D cell lysate.Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected Musashi-2 in HeLa cells.Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Musashi-2 in neurons and glial cells of rat pons tissues and in neurons and astrocytes of rat frontal cortex tissues. View All» Control: PC-12 cell lysate View All» Quality Assurance: Evaluated by Western Blot in PC-12 cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected Musashi-2 in 10 µg of PC-12 cell lysate. View All» Purification Method: Protein G purified View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q96DH6 View All» Entrez Gene Number: NP_620412 View All» Gene Symbol: MSI2 View All» Alternate Names:
  • RNA-binding protein Musashi homolog 2

  • Musashi-2
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry

    • Immunohistochemistry
      View All» Entrez Gene Summary: This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Two transcript variants encoding distinct isoforms have been identified for this gene. View All» UniProt Summary: FUNCTION: RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system.SUBCELLULAR LOCATION: Cytoplasm. Note: Associated with polysomes.TISSUE SPECIFICITY: Ubiquitous; detected at low levels.INDUCTION: Up-regulated in astrocytes after brain injury.POST-TRANSLATIONAL MODIFICATION: Phosphorylated.INVOLVEMENT IN DISEASE: Note=Chromosomal aberrations involving MSI2 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with HOXA9; translocation t(7;17)(q32-34;q23).SEQUENCE SIMILARITIES: Belongs to the Musashi family. Contains 2 RRM (RNA recognition motif) domains. View All» Product Name: Anti-Musashi-2 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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