货号：MABE243

品牌：Merck Millipore

规格：EA

目录价：￥4520.00

市场价格：￥3842.00

会员价格：￥3616.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Histone H3. X/Y Antibody, clone 8H6-2111 | MABE243 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~17 kDa observed. An uncharacterized band at ~52 kDa may be observed in some cell lysates. View All» Immunogen: Ovalbumin-conjugated linear peptide corresponding to primate Histone H3.X/Y. View All» Clone: 8H6-2111 View All» Isotype: IgG2bκ View All» Background Information: Histone variants differ from their cononical histones in sequence and activity. They are deposited in chromatin by large multiprotein complexes and play different roles from their cononical histones, in nucleosome deposition, chromatin remodeling, and gene regulation. Histones H3.X and H3.Y are novel primate-specific variants of histone H3 which are highly expressed in the brain and in various cancer cell lines. Expression of H3.Y increases in response to stressful stimuli such as starvation, and knockdown of H3.Y results disrupts cell growth and cell cycle processes. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. Predicted to react with primate based on immunogen design. View All» Application Notes: Western Blot Analysis: 1 µg/mL of this antibody detected Histone H3.X/Y in serum starved U2OS cells (Wiedemann, S. M., et al. 2010. J Cell Biol. 190(5):777-791.)Immunocytochemistry Analysis: A representative lot from an independent laboratory detected Histone H3.X/Y in HeLa cells (Wiedemann, S. M., et al. 2010. J Cell Biol. 190(5):777-791.). View All» Control: Serum fed and serum starved [8 days] U2OS cells View All» Quality Assurance: Evaluated by Western Blot in Serum fed and serum starved [8 days] U2OS cells.Western Blot Analysis: 1 µg/mL of this antibody detected Histone H3.X/Y in 10 µg serum starved [8 days] U2OS cells. View All» Purification Method: Protein G purified View All» Presentation: Purified rat monoclonal IgG2bκ supernatant in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:

• Western Blotting

• Immunocytochemistry
  View All» Product Name: Anti-Histone H3. X/Y, clone 8H6-2111 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rat View All»
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