货号：MABE139

品牌：Merck Millipore

规格：100Ug

目录价：￥3670.00

市场价格：￥3119.50

会员价格：￥2936.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-human Ago4 clone 1B7-G11 Antibody | MABE139 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~98 kDa observed View All» Epitope: 0 View All» Immunogen: Recombinant protein corresponding to human Ago4. View All» Clone: 1B7-G11 View All» Isotype: IgG2aκ View All» Background Information: AGO4 (Argonaute 4), also known as EIF2C4 is involved in regulation of gene silencing via small RNA’s such as siRNA and miRNA. This protein contains both a PAZ and a PIWI domain characteristic of Argonaute family of proteins. Functionally Ago4 is the catalytic component of the RNA-induced silencing complex (RISC). As part of this multi-protein complex, Ago4 interacts with miRNAs to help mediate translational repression of targeted messages. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. View All» Application Notes: Immunoprecipitation Analysis: A representative lot was used by an indpendent laboratory in Jurkat and HeLa cell extract. (Azuma-Mukai, A., et al. (2008). Proc Natl Acad Sci USA. 104(23):7964-7969.) View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysate.Western Blot Analysis: A 1 µg/mL of this antibody detected Ago4 in 10 µg HeLa cell lysate. View All» Purification Method: Protein G purified View All» Presentation: Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9HCK5 View All» Entrez Gene Number: NP_060099 View All» Gene Symbol:

• EIF2C4

• AGO4

• KIAA1567
  View All» Alternate Names:
  • Protein argonaute-4

  • Argonaute4

  • hAgo4

  • Eukaryotic translation initiation factor 2C 4

  • eIF-2C 4

  • eIF2C 4
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunoprecipitation
      View All» Entrez Gene Summary: This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic containing PAZ and PIWI domains, and it may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of closely related family members including argonaute 3, and eukaryotic translation initiation factor 2C, 1. View All» UniProt Summary: FUNCTION: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV).SUBUNIT STRUCTURE: Interacts with EIF4B, IMP8, PRMT5, TNRC6A and TNRC6B.SUBCELLULAR LOCALIZATION: Cytoplasm › P-body View All» Product Name: Anti-Ago4, clone 1B7-G11 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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