货号：MABD76

品牌：Merck Millipore

规格：100UL

目录价：￥5207.00

市场价格：￥4425.95

会员价格：￥4165.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Oct-4 Antibody, clone 9B7 | MABD76 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~39 kDa observed View All» Immunogen: Recombinant protein corresponding to human Oct-4. View All» Clone: 9B7 View All» Isotype: IgG1κ View All» Background Information: The POU5F1 gene expresses the POU-domain transcription factor, Octamer-4 (Oct-4), which is widely regarded as a hallmark of pluripotent stem cells. The relationship of Oct-4 to pluripotent stem cells is indicated by its tightly restricted expression to undifferentiated pluripotent stem cells. Upon differentiation to somatic lineages, the expression of Oct-4 disappears rapidly. Unlike the majority of pluripotent stem cell markers, the biological role of Oct-4 has been well characterized. Studies performed in mice point to the critical role of Oct-4 in the establishment and/or maintenance of pluripotent stem cells in an uncommitted state. View All» Species Reactivity:

• Mouse

• Human
  View All» Species Reactivity Note: Demonstrated to react with Mouse. Predicted to react with Human based on immunogen design. View All» Application Notes: Immunohistochemistry Analysis: A previous lot was used by an independent laboratory in human lung tissue.Immunocytochemistry Analysis: A previous lot was used by an independent laboratory in COS7 cells. View All» Control: Mouse embryonic stem cell lysate View All» Quality Assurance: Evaluated by Western Blot in mouse embryonic stem cell lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected Oct-4 in 10 µg of mouse embryonic stem cell lysate. View All» Purification Method: Protein G purified View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q01860 View All» Entrez Gene Number: NP_002692 View All» Gene Symbol:
  • POU5F1

  • OCT3

  • OCT4

  • OTF3
    View All» Alternate Names:
    • POU domain, class 5, transcription factor 1

    • Octamer-binding protein 3

    • Oct-3

    • Octamer-binding protein 4

    • Oct-4

    • Octamer-binding transcription factor 3

    • OTF-3
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry

      • Immunofluorescence
        View All» Entrez Gene Summary: This gene encodes a transcription factor containing a POU homeodomain. This transcription factor plays a role in embryonic development, especially during early embryogenesis, and it is necessary for embryonic stem cell pluripotency. A translocation of this gene with the Ewing's sarcoma gene, t(6;22)(p21;q12), has been linked to tumor formation. Alternative splicing, as well as usage of alternative translation initiation codons, results in multiple isoforms, one of which initiates at a non-AUG (CUG) start codon. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. View All» UniProt Summary: FUNCTION: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.SUBUNIT STRUCTURE: Interacts with UBE2I and ZSCAN10 By similarity. Interacts with PKM2. Interacts with WWP2.SUBCELLULAR LOCATION: Nucleus. Note: Expressed in a diffuse and slightly punctuate pattern.TISSUE SPECIFICITY: Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues. View All» Product Name: Anti-Oct-4 Antibody, clone 9B7 | MABD76 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Mouse View All»
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