货号：MABD41

品牌：Merck Millipore

规格：EA

目录价：￥3615.00

市场价格：￥3072.75

会员价格：￥2892.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-CD150 Antibody, clone 9D1 | MABD41 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: 38 kDa calculated View All» Epitope: Extracellular Domain View All» Immunogen: Recombinant protein corresponding to the extracellular region of mouse CD150. View All» Clone: 9D1 View All» Isotype: IgG1κ View All» Background Information: CD150 (also known as signaling lymphocyte activation molecule [SLAM] family member 1) is a self-ligand cell surface glycoprotein expressed on T cells, B cells, macrophages, and dendritic cells. CD150 plays an important role in adhesion and signaling between T cells and antigen-presenting cells (APCs), and it is involved in two major immune functions: costimulation of T-cell proliferation and augmentation of the interferon response. CD150 is the prototypical member of a growing family of glycoprotein receptors on hematopoietic stem cells known as the SLAM family, which includes CD229, CD84, CD244, SF2000/Ly108, SF2001, and 19A(CRACC). Members of this family are defined by one or more cytoplasmic tyrosine motifs. View All» Species Reactivity: Mouse View All» Species Reactivity Note: Demonstrated to react with mouse. View All» Application Notes: Immunoprecipitaiton Analysis: A previous lot was used by an independent laboratory in IP (Howie, D., et al. (2002). Blood. 100(8):2899-2907.) View All» Control: BALB/c thymus cells View All» Quality Assurance: Evaluated by Flow Cytometry in BALB/c thymus cells.Flow Cytometry Analysis: 1 µg of this antibody detected CD150 in BALB/c thymus cells. View All» Purification Method: Protein G Purified View All» Presentation: Purified rat monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9QUM4 View All» Entrez Gene Number: NP_038758 View All» Gene Symbol:

• CDw150

• CD150

• SLAM

• IPO-3

• CDW150

• SLAMF1
  View All» Alternate Names:
  • signaling lymphocytic activation molecule family member 1

  • signaling lymphocytic activation molecule

  • CD150 antigen
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Flow Cytometry

    • Immunoprecipitation
      View All» UniProt Summary: FUNCTION: High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.SUBUNIT STRUCTURE: Interacts with INPP5D/SHIP1 By similarity. Interacts (via cytoplasmic domain) with SH2D1A. Interacts (upon tyrosine phosphorylation with) PTPN11, but not with SHP-1.SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Note: Present on the surface of B-cells and T-cells.DOMAIN: The most membrane-proximal SH2-binding motif interacts with SH2 domain of SH2D1A and does not need to be phosphorylated on tyrosine residues By similarity.PTM: Phosphorylated.SEQUENCE SIMILARITIES: Contains 1 Ig-like C2-type (immunoglobulin-like) domain.Contains 1 Ig-like V-type (immunoglobulin-like) domain. View All» Product Name: Anti-CD150, clone 9D1 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Rat View All»
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