货号：MABC64

品牌：Merck Millipore

规格：100MIG

目录价：￥4264.00

市场价格：￥3624.40

会员价格：￥3411.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-DRAM2 Antibody | MABC64 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~29 kDa observed View All» Immunogen: Linear peptide corresponding to the human DRAM2 View All» Clone: 4H6.1 View All» Isotype: IgG2aκ View All» Background Information: Damage-Regulated Autophagy Modulator (DRAM) is a lysosomal protein that acts as an effector molecule that is critical for autophagy and p53-mediated apoptosis. In humans, there are 5 known proteins that show significant homology to DRAM. The closest of these proteins is DRAM2, which displays 67% conservation when compared to DRAM. However, unlike DRAM, DRAM2 is not induced by p53 or p73. Additionally, it does not modulate autophagy in contrast with DRAM. DRAM2 is known to be co-localized with DRAM in lysosomes, and co-expression with DRAM is shown to significantly increase cell death. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. View All» Control: Human placenta tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human placenta tissue lysate.Western Blot Analysis: 1 µg/mL dilution detected DRAM2 in 10 µg of human placenta tissue lysate. View All» Purification Method: Protein G Purified View All» Presentation: Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q6UX65 View All» Entrez Gene Number: NP_848549 View All» Gene Symbol:

• DRAM2

• TMEM77
  View All» Alternate Names:
  • DNA damage-regulated autophagy modulator protein 2

  • Transmembrane protein 77
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Induces apoptotic cell death when co-expressed with DRAM1.SUBCELLULAR LOCALIZATION: Lysosome membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Expression is down-regulated in ovarian tumors (at protein level). Widely expressed with highest levels in placenta and heart. Not detected in brain or thymus. View All» Product Name: Anti-DRAM2 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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