货号：MABC62

品牌：Merck Millipore

规格：100Y56

目录价：￥4264.00

市场价格：￥3624.40

会员价格：￥3411.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-DRAM1 Antibody | MABC62 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~26 kDa observed View All» Immunogen: KLH-conjugated linear peptide corresponding to human DRAM1. View All» Clone: 16F3.1 View All» Isotype: IgG1κ View All» Background Information: DNA damage regulated autophagy modulator 1 (DRAM1) is a lysosomal protein used by p53 to regulate macroautophagy. DRAM1 is necessary for p53-mediated apoptosis. DRAM1 is often found to be under-expressed in many tumor types. DRAM1 has also been found to be regulated by p73. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. View All» Application Notes: Immunohistochemistry Analysis: A 1:400 dilution from a representative lot detected DRAM1 in normal human placental villi. View All» Control: Human placenta tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human placenta tissue lysate.Western Blot Analysis: A 1:2,000 dilution of this antibody detected DRAM1 in 10 µg of human placenta tissue lysate. View All» Purification Method: Protein G Purified View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q8N682 View All» Entrez Gene Number: NP_060840 View All» Gene Symbol:

• DRAM1

• DRAM
  View All» Alternate Names:
  • DNA damage-regulated autophagy modulator protein 1

  • Damage-regulated autophagy modulator
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry
      View All» Entrez Gene Summary: Summary: This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy.SUBCELLULAR LOCATION: Lysosome membrane; Multi-pass membrane protein.INDUCTION: By p53/TP53 and TP73/p73. Directly activated by p53/TP53. Significantly down-regulated in tumor cell lines by methylation-dependent transcriptional silencing.SEQUENCE SIMILARITIES: Belongs to the DRAM/TMEM150 family.SEQUENCE CAUTION: The sequence BAA92091.1 differs from that shown. Reason: Erroneous initiation. View All» Product Name: Anti-DRAM1 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Mouse View All»
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