货号：MABC48

品牌：Merck Millipore

规格：100Ug

目录价：￥4967.00

市场价格：￥4221.95

会员价格：￥3973.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Anterior gradient protein 2 homolog Antibody, clone 7A10 | MABC48 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Specific for Anterior gradient protein 2 homolog and does not detect Anterior gradient protein 3 homolog. View All» Molecular Weight: ~18 kDa observed View All» Immunogen: Linear peptide corresponding to a sequence unique to human Anterior gradient protein 2 homolog and not to human Anterior gradient protein 3 homolog. View All» Clone: 7A10 View All» Isotype: IgG1κ View All» Background Information: Anterior gradient protein 2 homolog (AGR2) (also known as secreted cement gland protein XAG-2 homolog) is thought to be a metastasis-inducing protein in breast cancer models and may be used as a means of detecting the outcome of hormonally treated patients with breast cancer. AGR2 may also play an important role in intestinal mucus production. Recent researched has also linked AGR2 to metastasis. Lower levels of AGR expression in prostate cancer may be highly predictive of the reoccurrence of disease even after a prostatectomy. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Application Notes: Immunocytochemistry Analysis: A previous lot was used by an independent laboratory in IC on primary carcinomas (Barraclough, D., et al. (2009). Am J Pathol. 175:1848–1857). View All» Control: MCF-7 cell lysate View All» Quality Assurance: Evaluated by Western Blot in MCF-7 cell lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected Anterior gradient protein 2 homolog in 10 µg of MCF-7 cell lysate. View All» Purification Method: Protein G Purified View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O95994 View All» Entrez Gene Number: NP_006399 View All» Gene Symbol:

• AGR2

• GOB-4

• AG2

• HAG-2

• XAG-2

• PDIA17

• AG-2

• HPC8

• hAG-2
  View All» Alternate Names:
  • anterior gradient homolog 2 (Xenopus laevis)

  • anterior gradient 2 homolog

  • protein disulfide isomerase family A, member 17

  • Secreted cement gland protein XAG-2 homolog

  • anterior gradient protein 2 homolog

  • secreted cement gland homolog

  • anterior gradient 2 homolog (Xenopus laevis)
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry
      View All» UniProt Summary: FUNCTION: Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. SUBUNIT STRUCTURE: Interacts with LYPD3 and DAG1 (alphaDAG1). Interacts with MUC2; disulfide-linked. SUBCELLULAR LOCATION: Secreted. Endoplasmic reticulum (By similarity).TISSUE SPECIFICTY: Expressed strongly in trachea, lung, stomach, colon, prostate and small intestine. Expressed weakly in pituitary gland, salivary gland, mammary gland, bladder, appendix, ovary, fetal lung, uterus, pancreas, kidney, fetal kidney, testis, placenta, thyroid gland and in estrogen receptor (ER)-positive breast cancer cell lines. SEQUENCE SIMILARITIES: Belongs to the AGR family. View All» Product Name: Anti-Anterior gradient protein 2 homolog, clone 7A10 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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