货号：MABC41

品牌：Merck Millipore

规格：

目录价：￥4264.00

市场价格：￥3624.40

会员价格：￥3411.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-BCAP31 Antibody, clone 3D11 | MABC41 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~28 kDa observed View All» Immunogen: Recombinant protein corresponding to human BCAP31. View All» Clone: 3D11 View All» Isotype: IgG2bκ View All» Background Information: BCAP31 (B-cell receptor-associated protein 31) is more commonly known as BAP31. BCAP31 is an integral protein of the endoplasmic reticulum (ER) and controls the export of other integral proteins to the secretion pathways and can manipulate the cell surface. BCAP31 is also associated with shaping cell sensitivity to ER stress. BCAP31 has two caspase cleavage sites that can be used in certain apoptotic pathways, and BCAP31 binds with Fis1 to create a bridge from the ER to the mitochondria for apoptosis signaling. BCAP31 is also linked to the E5 proteins of the human papilloma virus and may play a role in the viruses’ life cycle. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. View All» Application Notes: Immunocytochemistry Analysis: A representative lot was used by an independent laboratory to detect BCAP31 in HeLa cells (Ignacio Pino, CDI Laboratories). View All» Control: Human adrenal tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human adrenal tissue lysate.Western Blot Analysis: A 1:500 dilution of this antibody detected BCAP31 in 10 µg of human adrenal tissue lysate. View All» Purification Method: Protein G Purified View All» Presentation: Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P51572 View All» Entrez Gene Number: NP_001132913 View All» Gene Symbol:

• BCAP31

• BAP31
  View All» Alternate Names:
  • B-cell receptor-associated protein 31

  • BCR-associated protein 31

  • Bap31

  • 6C6-AG tumor-associated antigen

  • Protein CDM

  • p28
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of the B-cell receptor associated protein 31 superfamily. The encoded protein is a multi-pass transmembrane protein of the endoplasmic reticulum that is involved in the anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi and in the caspase 8-mediated apoptosis. Microdeletions in this gene are associated with the contiguous ABCD1/DXS1375E deletion syndrome. Two pseudogenes have been identified on chromosome 16. Alternatively spliced transcript variants encoding distinct isoforms have been described although the biological validity of some of the variants has not been determined. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis. SUBUNIT STRUCTURE: Homodimer and heterodimer with BCAP29. Binds CASP8 (isoform 9) as a complex containing BCAP31, BCAP29, BCL2 and/or BCL2L1. Interacts with VAMP3, VAMP1 and membrane IgD immunoglobulins. May interact with ACTG1 and non-muscle myosin II. Interacts with PTPLB. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Note: May shuttle between the ER and the intermediate compartment/cis-Golgi complex. TISSUE SPECIFICITY: Ubiquitous.PTM: Cleaved by CASP8 and other caspases.INVOVLEMENT IN DISEASE: Note=BCAP31 is deleted in the chromosome Xq28 deletion syndrome which involves BCAP31 and the and the promoter region of ABCD1.SEQUENCE SIMILARITIES: Belongs to the BCAP29/BCAP31 family. View All» Product Name: Anti-BCAP31, clone 3D11 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Purified View All» Host: Mouse View All»
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