货号：MABC24

品牌：Merck Millipore

规格：

目录价：￥4383.00

市场价格：￥3725.55

会员价格：￥3506.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-LAMP-2 Antibody, clone M3/84 | MABC24 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: 46 kDa calculated View All» Immunogen: Murine macrophage membranes View All» Clone: M3/84 View All» Isotype: IgG1κ View All» Background Information: Lysosome-associated membrane protein 2 (LAMP-2) is a highly glycosolated protein belonging to the lysosome-associated membrane protein family. This group pf proteins composes a significant portion of the lysosomal membrane and are considered crucial mediators for cellular adhesion by interacting with carbohydrate receptors. LAMP-2 is a profuse and critical component of the lysosomal membrane as it has been implicated in playing a role in lysosomal biogenesis. It also appears to be involved in later stages of phagocytosis and autophagy, where it may act to protect the lysosomal membrane from being digested, assist in signal transduction, moderate levels of acidity within the lysosomal environment, and participate in adhesion. Mutations in LAMP-2 expression have been associated with lysosomal storage diseases or LSDs, along with Danon disease, an X-linked disorder characterized by skeletal myopathy, mental retardation, and hypertrophic cardiomyopathy. View All» Species Reactivity: Mouse View All» Species Reactivity Note: Demonstrated to react with mouse. View All» Application Notes: Immunoprecipitation Analysis: A previous lot was used by an independent laboratory in IP (Springer, T., et al. (1981). The Journal of Biological Chemistry. 256(8):3833-3839).Immunohistochemistry Analysis: A previous lot was used by an independent laboratory in IH (Springer, T., et al. (1983). Am J Pathol. 111(1):112-24).Immunofluorescence Analysis: A previous lot was used by an independent laboratory in IF (Deng. Y., et al. (1998). Proc. Nati. Acad. Sci. USA. 85:3860-3864). View All» Control: NIH/3T3 cells View All» Quality Assurance: Evaluated by Flow Cytometry in NIH/3T3 cells.Flow Cytometry Analysis: 10 µg of this antibody detected LAMP-2 in NIH/3T3 cells. View All» Purification Method: Protein G Purified View All» Presentation: Purified rat monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P17047 View All» Entrez Gene Number: NP_001017959 View All» Gene Symbol:

• CD107b

• LAMPB

• LGP110

• LAMP-2
  View All» Alternate Names:
  • lysosomal-associated membrane protein 2

  • CD107 antigen-like family member B

  • CD107b antigen
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Flow Cytometry

    • Immunoprecipitation

    • Immunohistochemistry

    • Immunofluorescence
      View All» UniProt Summary: FUNCTION: Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens.SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note: This protein shuttles between lysosomes, endosomes, and the plasma membrane.PTM: O- and N-glycosylated; some of the N-linked glycans are polylactosaminoglycans (By similarity).SEQUENCE SIMILARITIES: Belongs to the LAMP family. View All» Product Name: Anti-LAMP-2, clone M3/84 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rat View All»
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