货号：MABC12

品牌：Merck Millipore

规格：

目录价：￥4439.00

市场价格：￥3773.15

会员价格：￥3551.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-TRAIL Antibody, clone N2B2 | MABC12 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes TRAIL at the extracellular domain. View All» Molecular Weight: 34 kDa calculated View All» Epitope: Extracellular domain View All» Immunogen: Mouse TRAIL transfectant View All» Clone: N2B2 View All» Isotype: IgG2aκ View All» Background Information: Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel member in the TNF family was recently identified and designated TRAIL (for TNF-related apoptosis-inducing ligand) and Apo-2L (for Apo-2 ligand) (1,2). TRAIL is a type II membrane protein and is expressed in a variety of human tissues. Two novel death domain containing receptors DR4 and DR5 have been identified as the receptor for TRAIL (3-5). Like TNF and Fas ligand, TRAIL induces apoptosis and NF-kB activation in many tissues and cells. View All» Species Reactivity: Mouse View All» Species Reactivity Note: Demonstrated to react with Mouse. View All» Application Notes: Flow Cytometry Analysis: A representative lot was used by an independent laboratory in B6 splenocytes. (Kayagaki, N., et al. (1996). J Immunol. 163:1906-1913.) View All» Control: 2PK-3 cells View All» Quality Assurance: Evaluated by Flow Cytometry in 2PK-3 cells.Flow Cytometry Analysis: 0.2 µg of this antibody detected TRAIL in 2PK-3 cells. View All» Purification Method: Protein G purified View All» Presentation: Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P50592 View All» Entrez Gene Number: NP_033451 View All» Gene Symbol:

• TRAIL

• Trail

• Tnfsf10
  View All» Alternate Names:
  • Tumor necrosis factor ligand superfamily member 10

  • TNF-related apoptosis-inducing ligand

  • Protein TRAIL

  • CD253

  • TRAIL
    View All» Sales Restrictions: Not available for sale in Japan. View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Flow Cytometry View All» UniProt Summary: FUNCTION: Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.SUBUNIT STRUCTURE: Homotrimer (By similarity).SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein Potential. TISSUE SPECIFICITY: Widespread.SEQUENCE SIMILARITIES: Belongs to the tumor necrosis factor family. View All» Product Name: Anti-TRAIL, clone N2B2 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rat View All»
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