货号：MABC113

品牌：Merck Millipore

规格：

目录价：￥4383.00

市场价格：￥3725.55

会员价格：￥3506.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-USP18 (UBP43) Antibody, clone 1C3.1 | MABC113 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~43 kDa observed. An uncharacterized band at ~230 kDa may be observed in some cell lysates. View All» Immunogen: KLH-conjugated linear peptide corresponding to human USP18 (UBP43). View All» Clone: 1C3.1 View All» Isotype: IgMκ View All» Background Information: The ubiqutin specific protease 18 (USP18; or UBP43) is a ubiquitin-specific protease that cleaves adducts of the ubiquitin-like modifier ISG15 from target substrates, and consequently regulates levels of the ISG15 protein. USP18 may be involved in multiple cellular processes including proliferation, inflammation, and stress responses. USP18 may also play an important role in innate immune responses to pathogenic organisms. Previous studies have reported that levels of ISG15-modified proteins increase after viral infection, and this is controlled by USP18. In addition, USP18 binds to type 1 INF receptors and inhibits their signaling by blocking their interaction with Jak2/STAT effector molecules, thereby downregulating INF signaling. View All» Species Reactivity:

• Human

• Rat
  View All» Species Reactivity Note: Demonstrated to react wtih Human and Rat. View All» Control: HepG2 cell lysate View All» Quality Assurance: Evaluated by Western Blot in HepG2 cell lysate.Western Blot Analysis: A 1:2,000 dilution of this antibody detected USP18 (UBP43) in 10 µg of HepG2 cell lysate. View All» Purification Method: Purified by ion-exchange chromatography View All» Presentation: Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9UMW8 View All» Entrez Gene Number: NP_059110 View All» Gene Symbol:
  • USP18

  • ISG43
    View All» Alternate Names:
    • Ubl carboxyl-terminal hydrolase 18

    • 43 kDa ISG15-specific protease

    • hUBP43

    • ISG15-specific-processing protease

    • Ubl thioesterase 18
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Product Name: Anti-USP18 (UBP43), clone 1C3.1 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Mouse View All»
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