货号：MAB8991

品牌：Merck Millipore

规格：100UL

目录价：￥4663.00

市场价格：￥3963.55

会员价格：￥3730.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-LASP-1 Antibody, clone 8C6 | MAB8991 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes human Lasp-1 View All» Immunogen: Synthetic peptide corresponding to an internal sequence of human Lasp-1. View All» Clone: 8C6 View All» Isotype: IgG1 View All» Background Information: Lasp-1 is an actin-binding scaffolding protein that is overexpressed in 8-12% of breast cancers and is correlated to increased incidences of metastasis. Lasp-1 localizes to newly forming focal adhesions and membrane ruffles during cell migration. View All» Species Reactivity: Human View All» Application Notes: Immunohistochemistry (frozen sections): 1:200 Immunocytochemistry: 1:200 Western blot: 1:2,000 Immunoprecipitation: 1:250-1:1,000 Indirect ELISA: 1:1,000 Optimal working dilutions must be determined by end user. View All» Presentation: Ascites fluid. Liquid containing no preservatives. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q14847 View All» Entrez Gene Number: NM_006148.1 View All» Gene Symbol:

• LASP1

• LASP-1

• MLN50

• Lasp-1
  View All» Alternate Names: LIM and SH3 Domain Protein 1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Immunoprecipitation

  • Western Blotting

  • Immunocytochemistry

  • Immunohistochemistry
    View All» Entrez Gene Summary: This gene encodes a member of a LIM protein subfamily which is characterized by a LIM motif and a domain of Src homology region 3. This protein functions as an actin-binding protein and possibly in cytoskeletal organization. View All» UniProt Summary: FUNCTION: SwissProt: Q14847 # Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity).SIZE: 261 amino acids; 29717 Da SUBUNIT: Interacts with F-actin (By similarity).SUBCELLULAR LOCATION: Cytoplasm, cell cortex (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Associated with the F-actin rich cortical cytoskeleton (By similarity).PTM: Phosphorylated (By similarity).SIMILARITY: SwissProt: Q14847 ## Contains 1 LIM zinc-binding domain. & Contains 2 nebulin repeats. & Contains 1 SH3 domain. View All» Brand Family: Chemicon View All» Product Name: Anti-LASP-1 Antibody, clone 8C6 | MAB8991 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Ascites View All» Host: Mouse View All»
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