货号：MAB88058

品牌：Merck Millipore

规格：

目录价：￥3552.00

市场价格：￥3019.20

会员价格：￥2841.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-p21waf1 Antibody, clone HZ52 | MAB88058 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Monoclonal antibody MAB88058 recognizes an 18 to 21 kDa protein, identified as the p21WAF1/cip1/sdi1/pic1 tumor suppressor protein. MAB88058 is highly specific to p21 and shows no cross-reaction with other closely related mitotic inhibitors. p21WAF1 is a specific inhibitor of cdk's and a tumor suppressor involved in the pathogenesis of a variety of malignancies. Expression of p21WAF1 is induced by wild type, but not mutant, p53 suppressor protein. CELLULAR LOCALIZATION: Predominant nuclear View All» Immunogen: Full length human recombinant p21 protein. View All» Clone: HZ52 View All» Isotype: IgG1 View All» Species Reactivity:

• Bovine

• Human

• Mouse

• Rat
  View All» Application Notes: Immunohistochemistry: 2-5 μg/mL on formalin-fixed paraffin-embedded tissue sections. High temperature antigen retrieval in 10mM citrate buffer, pH 6.0, is strongly recommended. Flow Cytometry Immunoprecipitation: 2 μg (antibody)/mg protein lysate. The use of protein G to precipitate antigen-antibody complexes is recommended. Optimal working dilutions must be determined by end user. View All» Control: POSITIVE CONTROL: Ls174T, Raji, Hs27, U20S, MCF-7 cells. Rat/Mouse embryonic fibroblast cells treated with DNA damaging agents. Skin, colon, or breast carcinoma. View All» Presentation: Purified immunoglobulin. Liquid containing 10 mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide. View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 12 months. View All» UniProt Number: P38936 View All» Entrez Gene Number:
  • NM_000389.2

  • NM_078467.1
    View All» Gene Symbol:
    • CDKN1A

    • P21

    • MDA-6

    • SDI1

    • MDA6

    • p21

    • p21CIP1

    • PIC1

    • CIP1

    • CDKN1

    • WAF1

    • CAP20
      View All» Alternate Names: Cip1; MDA-6 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported. View All» Key Applications:
      • Flow Cytometry

      • Immunoprecipitation

      • Immunohistochemistry (Paraffin)
        View All» UniProt Summary: FUNCTION: SwissProt: P38936 # May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression.SIZE: 164 amino acids; 18119 Da SUBCELLULAR LOCATION: Cytoplasm. Nucleus.TISSUE SPECIFICITY: Expressed in all adult human tissues, with 5- fold lower levels observed in the brain.PTM: Phosphorylation of Thr-145 by Akt or of Ser-146 by PKC impairs binding to PCNA.SIMILARITY: SwissProt: P38936 ## Belongs to the CDI family. View All» Brand Family: Chemicon View All» Product Name: Anti-p21waf1 Antibody, clone HZ52 | MAB88058 View All» Concentration: 200 ug/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Purified View All» Host: Mouse View All»
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