货号：05-1564MG

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-mTOR Antibody, clone 21A12.2 | 05-1564MG View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody only detects mTOR. View All» Molecular Weight: ~289 kDa View All» Immunogen: Full-length human mTOR View All» Clone: clone 21A12.2 View All» Isotype: IgG1κ View All» Background Information: mTOR (Mammalian Target of Rapamycin, FRAP, RAPT or RAFT) is a large 289 kDa Ser/Thr protein kinase that regulates cell cycle progression, cell growth, protein synthesis, ribosome biogenesis, and autophagy. mTOR is an evolutionarily conserved member of the Phosphoinositol Kinase-related Kinase (PIKK) family whose activity is regulated by phosphorylation on Ser2448 by Akt in response to insulin or muscle activity. mTOR is the central component of two multimeric kinase complexes consisting of mTOR and numerous other mTOR binding proteins. These two multimeric protein complexes are designated mTORC1 and mTORC2. mTORC1 consists of at least mTOR, Raptor, and GL. mTORC1 is known to play a central role in insulin signaling, which is crucial in maintaining metabolic homeostasis. The other mTOR complex, mTORC2, is made up of at least mTOR, Rictor, GL, Sin1, Protor 1 and 2. TORC2 affects cell proliferation and survival primarily by phosphorylating the hydrophobic motif of Akt on Ser473. TORC2 complex is also known to effect cytoskeletal organization and migration by exerting its effects through Rac, Rho, and PKC. Defects in both mTOR complexes are associated with a variety of diseases, including cancer and diabetes. View All» Species Reactivity: Human View All» Species Reactivity Note: Human. Other species to be tested. View All» Application Notes: Confocal Immunofluorescent Immunocytochemistry: View All» Control: HEK293 cell lysates View All» Quality Assurance: Evaluated by Western Blotting on HEK293 cell lysates.Western Blotting Analysis: A 1:1,000 dilution of this antibody was used to detect mTOR in HEK293 cell lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal in PBS, no preservatives. View All» Storage Conditions: Stable for 1 year at 2-8ºC from date of receipt. View All» UniProt Number: Q6R327 View All» Entrez Gene Number: NP_004949.1 View All» Gene Symbol:

• DKFZp686B11164

• KIAA1999

• MGC39830

• mAVO3

• pianissimo
  View All» Alternate Names:
  • TORC2-specific protein AVO3

  • rapamycin-insensitive companion of mTOR
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry
      View All» UniProt Summary: FUNCTION: Plays an essential role in embryonic growth and development By similarity. Part of the TORC2 complex which plays a critical role in AKT1 'Ser-473' phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization. SUBUNIT STRUCTURE: Forms part of the target of rapamycin 2 complex (TORC2) comprised of FRAP1, LST8, PROTOR1, RICTOR and MAPKAP1. TORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to FRAP1 and PROTOR1 within the TORC2 complex. May interact with PROTOR2.SEQUENCE CAUTION: The sequence CAH18135.1 differs from that shown. Reason: Frameshift at position 251. View All» Product Name: Anti-mTOR, clone 21A12.2 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 1 mg View All» Format: Purified View All» Host: Mouse View All»
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