货号：05-1520

品牌：Merck Millipore

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目录价：￥3639.00

市场价格：￥3093.15

会员价格：￥2911.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-HnRNP C1/C2 Antibody, clone 4F4 | 05-1520 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes HnRNP C1/C2. View All» Molecular Weight: Observed ~ 37 kDa/39 kDa. The calculated MW is C1 for 32.3 kDa and C2 for 33.8 kDa. View All» Epitope: Unknown View All» Immunogen: RNP’s eluted from oligo (dT) cellulose column of human HnRNP C1/C2. View All» Clone: 4F4 View All» Isotype: IgG2bκ View All» Background Information: The hnRNP C proteins (C1/C2) are nuclear pre-mRNA-binding proteins that belong to the large RNP motif family of RNA-binding proteins. The proteins encoded by this gene act as a tetramer and are involved in the assembly of 40S hnRNP particles. The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA). These proteins aassociate with pre-mRNAs in the nucleus and influence pre-mRNA processing and other aspects of mRNA metabolism and transport. In vivo, hnRNP C proteins have been found to interact with Grb2. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with human. Predicted to react with mouse based on 100% sequence homology. View All» Control: HeLa nuclear extract lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa nuclear extract lysate.Western Blot Analysis: 0.01 µg/ml of this antibody detected HnRNP C1/C2 on 10 µg of HeLa nuclear extract lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P07910 View All» Entrez Gene Number: NP_001070910.1 View All» Gene Symbol:
  • HNRNPC

  • C1

  • C2

  • HNRNP

  • HNRPC

  • SNRPC

  • hnRNPC
    View All» Alternate Names:
    • heterogeneous nuclear ribonucleoprotein C

    • heterogeneous nuclear ribonucleoprotein C (C1/C2)

    • hnRNP C1 / hnRNP C2

    • nuclear ribonucleoprotein particle C1 protein

    • nuclear ribonucleoprotein particle C2 protein
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. SUBUNIT STRUCTURE: Tetramer composed of 3 copies of isoform C1 and 1 copy of isoform C2. Assembly of 3 tetramers with bound pre-mRNA gives rise to a 19S complex that interacts with HNRNPA2B1 tetramers. Component of the 40S hnRNP particle. Identified in the spliceosome C complex, at least composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRNPA1, HNRNPA2B1, HNRPA3, HNRNPC, HNRPF, HNRPH1, HNRPK, HNRPM, HNRNPR, HNRNPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNW1, SRRM1, SRRM2, SYF2, SYNCRIP, TFIP11, THOC4, U2AF1, WDR57, XAB2 and ZCCHC8. Interacts with IGF2BP1.SUBCELLULAR LOCATION: Nucleus. Note: Component of ribonucleosomes.PTM: Phosphorylated on Ser-260 and Ser-299 in resting cells. Phosphorylated on Ser-253 and on 1 serine residue in the poly-Ser stretch at position 238 in response to hydrogen peroxide. Sumoylated. Sumoylation reduces affinity for mRNA. SEQUENCE SIMILARITIES: Belongs to the RRM HNRPC family. RALY subfamily.Contains 1 RRM (RNA recognition motif) domain. View All» Product Name: Anti-HnRNP C1/C2, clone 4F4 Antibody (05-1520) View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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