货号：05-1519

品牌：Merck Millipore

规格：EA

目录价：￥3468.00

市场价格：￥2947.80

会员价格：￥2774.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-hnRNP K/J Antibody, clone 3C2 | 05-1519 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes hnRNP K/J. View All» Molecular Weight: Calculated MW: hnRNP K 51 kDa, hnRNP J 49 kDa. Observed MW: 55 kDa and 53kDa respectively. View All» Epitope: Unknown View All» Immunogen: Full length human hnRNP K/J. View All» Clone: 3C2 View All» Isotype: IgG2bκ View All» Background Information: The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA) and associate with pre-mRNAs in the nucleus. These complexes are associated with pre-mRNA processing and other aspects of mRNA metabolism and transport. Family members hnRNPJ and hnRNP K act as substrates for pre-mRNA processing prior to translation in the cytoplasm. They represent one of the major subsets of poly(C)-binding proteins (PCBPs) most commonly found in mammalian cells. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Application Notes: Immunoprecipitation Analysis: A representative lot of this antibody was used by an independent laboratory in IP. (Mili, S., et al. (2001). Mol. Cell. Biol. 21:7307 - 7319.)Immunocytochemistry Analysis: A representative lot of this antibody was used by an independent laboratory in IP. (Kurt E. Gustin, K., et al. (2002). J. Virol. 76:8787 - 8796.) View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysate.Western Blot Analysis: 0.01 µg/mL of this antibody detected hnRNP K/J on 10 µg of HeLa cell lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P61978 View All» Entrez Gene Number: NP_002131 View All» Gene Symbol:

• HNRPK

• hnRNP K

• TUNP

• CSBP
  View All» Alternate Names:
  • heterogeneous nuclear ribonucleoprotein K

  • transformation upregulated nuclear protein

  • Transformation up-regulated nuclear protein

  • dC-stretch binding protein
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunoprecipitation

    • Immunocytochemistry
      View All» Entrez Gene Summary: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progession. Several alternatively spliced transcript variants have been described for this gene, however, not all of them are fully characterized. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA.SUBUNIT STRUCTURE: Interacts with RBM42 and ZIK1 by similarity. Identified in the spliceosome C complex, at least composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRPA1, HNRPA2B1, HNRPA3, HNRPC, HNRPF, HNRPH1, HNRNPK, HNRPM, HNRPR, HNRPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNW1, SRRM1, SRRM2, SYF2, SYNCRIP, TFIP11, THOC4, U2AF1, WDR57, XAB2 and ZCCHC8. Interacts with ANKRD28. Interacts with HCV core protein. Interacts with ASFV p30 protein. SUBCELLULAR LOCATION: Cytoplasm. Nucleus › nucleoplasm. Note: In case of ASFV infection, there is a shift in the localization which becomes predominantly nuclear. PTM: Arg-296 and Arg-299 are dimethylated, probably to asymmetric dimethylarginine. SEQUENCE SIMILARITIES: Contains 3 KH domains.MASS SPECTROMETRY: Molecular mass is 50976.25 Da from positions 1 - 463 (P61978-1). Determined by MALDI. View All» Product Name: Anti-hnRNP K/J, clone 3C2 Antibody (05-1519) View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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