货号：05-1518

品牌：Merck Millipore

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目录价：￥3908.00

市场价格：￥3321.80

会员价格：￥3126.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-hnRNP L Antibody, clone 4D11 | 05-1518 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~64 kDa observed View All» Immunogen: Human hnRNP proteins (from HeLa cells) purified by affinity chromatography on ssDNA agarose. View All» Clone: 4D11 View All» Isotype: IgG1κ View All» Background Information: Heterogeneous nuclear ribonucleoprotein L (HnRNP-L) is a polypyrimidine tract-binding protein (PTB)-binding protein and is commonly found in the nucleoplasm. HnRNP-L appears to be involved in transcription, pre-mRNA processing, mature mRNA transport to the cytoplasm, and translation. HnRNP-L binds to an RNA sequence element in a very sequence-specific manner that permit intron-independent gene expression. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Application Notes: Immunoprecipitation: A representative lot detected hnRNP L in IP. (Topp, J.D., et al. (2008). RNA. 14:2038–2049.) View All» Control: HepG2 cell lysate View All» Quality Assurance: Evaluated by Western Blot in HepG2 cell lysate.Western Blot Analysis: 0.01 µg/mL of this antibody detected hnRNP L on 10 µg of HepG2 cell lysate. View All» Purification Method: Protein G View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P14866 View All» Entrez Gene Number: NP_001005335 View All» Gene Symbol:

• HNRNPL

• HNRPL

• hnRNP L
  View All» Alternate Names: heterogeneous nuclear ribonucleoprotein L View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Western Blotting

  • Immunoprecipitation
    View All» Entrez Gene Summary: Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. L is associated with most nascent transcripts including those of the landmark giant loops of amphibian lampbrush chromosomes.SUBUNIT STRUCTURE: Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with HNRPLL. SUBCELLULAR LOCATION: Nucleus › nucleoplasm. Cytoplasm. Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs. PTM: Several isoelectric forms of the L protein are probably the results of post-translational modifications.SEQUENCE SIMILARITIES: Contains 3 RRM (RNA recognition motif) domains.SEQUENCE CAUTION: The sequence CAA34261.1 differs from that shown. Reason: Erroneous initiation. View All» Product Name: Anti-hnRNP L, clone 4D11 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Mouse View All»
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