货号：05-1500

品牌：Merck Millipore

规格：

目录价：￥3908.00

市场价格：￥3321.80

会员价格：￥3126.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Mad1 Antibody, clone 9B10 | 05-1500 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Mad1. View All» Immunogen: Full length recombinant Mad1. View All» Clone: 9B10 View All» Isotype: IgG2bκ View All» Background Information: Mitotic arrest deficient-like 1 (yeast) is also known as MAD1 and MAD1L1. It is part of the MAD1 family which is crucial to development. MAD1 acts as a checkpoint gene during mitotic spindle assembly. During anaphase and telophase MAD1 is located at the spindle mid-zone of the cell, where it prevents anaphase until the chromosome is aligned at the metaphase plate. During metaphase MAD1 is located at the centrosome. MAD1 participates in cell cycle control and tumor suppression. MAD1 functions as a homodimer and interacts with MAD2L1. It is thought that MAD1 recruits to MAD2, which then promotes binding of MAD2 to CDC20. View All» Species Reactivity: Human View All» Species Reactivity Note: Tested on Human cells. View All» Application Notes: ImmunoprecipitationImmunocytochemistry View All» Control: HeLa nuclear extract View All» Quality Assurance: Western Blot Analysis:1-5 µg/mL of this anti-Mad1, clone 9B10 detected Mad1 in HeLa nuclear extract. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG2b in buffer containing 0.1 M Tris-Glycine, (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8ºC from date of receipt. View All» UniProt Number: Q9Y6D9 View All» Gene Symbol:

• HsMAD1

• MAD1

• PIG9

• TP53I9

• TXBP181

• hMAD1
  View All» Alternate Names:
  • MAD1 (mitotic arrest deficient, yeast, homolog)-like 1

  • MAD1 mitotic arrest deficient-like 1 (yeast)

  • MAD1-like 1

  • MAD1-like 1 protein

  • Mitotic arrest deficient-like protein 1

  • Mitotic checkpoint MAD1 protein-homolog

  • Tax-binding protein 181

  • mitotic-arrest deficient 1, yeast, homolog-like 1

  • tumor protein p53 inducible protein 9
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry

    • Immunoprecipitation
      View All» UniProt Summary: FUNCTION: Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Ref.2STRUCTURE:Homodimer. Heterodimerizes with MAD2L1 in order to form a tetrameric MAD1L1-MAD2L1 core complex. Perturbation of the original MAD1L1-MAD2L1 structure by the spindle checkpoint may decrease MAD2L1 affinity for MAD1L1. CDC20 can compete with MAD1L1 for MAD2L1 binding, until the attachment and/or tension dampen the checkpoint signal, preventing further release of MAD2L1 on to CDC20. Also able to interact with the BUB1/BUB3 complex and the viral Tax protein. Ref.1SUBCELLULAR LOCATION: Nucleus. Note= From the beginning to the end of mitosis, it is seen to move from a diffusely nuclear distribution to the centrosome, to the spindle midzone and finally to the midbody. Ref.1TISSUE SPECIFICITY: Expressed weakly at G0/G1 and highly at late S and G2/M phase.Induction Increased by TP53. Ref.2PTM: Phosphorylated; by BUB1. Become hyperphosphorylated in late S through M phases or after mitotic spindle damage. Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.1 Ref.6 Ref.7 Ref.8 Ref.9 Ref.10 Ref.11 Ref.12 Ref.13DISEASE: Defects in MAD1L1 are involved in the development and/or progression of various types of cancer.SIMILARITY: Belongs to the MAD1 family.SEQUENCE CAUTION: The sequence AAC52059.1 differs from that shown. Reason: Frameshift at position 663. View All» Product Name: Anti-Mad1 Antibody, clone 9B10 | 05-1500 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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