货号：05-1424

品牌：Merck Millipore

规格：100Ug

目录价：￥4967.00

市场价格：￥4221.95

会员价格：￥3973.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Endoglin Antibody, clone P3D1 | 05-1424 View All» Replaces: 05-1424 is a recommended replacement for MAB2152 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Reacts with human endoglin. View All» Molecular Weight: ~71 kDa View All» Immunogen: Human resting umbilical vein endothelial cells. View All» Clone: P3D1 View All» Isotype: IgG2a View All» Background Information: Endoglin is a homodimeric integral membrane glycoprotein comprised of 95 kDa subunit. Endoglin is a component of the TGF-B receptor system that functions as an ancillary receptor influencing binding of the Transforming Growth Factor beta (TGF-β) family ligands to signaling receptors. Endoglin binds TGF-B1 and TGF-B3 with high affinity but does not bind TGF-B2. Endoglin is expressed by vascular endothelial cells and syncytiotrophoblasts of placenta and is weakly expressed by stromalfibroblasts. It is also expressed by U937 cells and activated macrophages. Endoglin expression is up regulated on activated endothelium in tissues undergoing angiogenesis, such as in tumors, or in cases of wound healing or dermal inflammation. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Human and mouse. Expected to react with rat based on sequence homology. View All» Application Notes: Immunohistochemistry: For use on acetone or paraformaldehyde fixed tissue.ELISA: A previous lot of this antibody was used in ELISA.Immunoprecipitation: A previous lot of this antibody was used in IP.Immunocytochemistry: A previous lot of this antibody was used in IC.Flow Cytometry: A previous lot of this antibody was used in FC.Optimal working dilutions must be determined by the end user. View All» Control: Jurkat cell lysate View All» Quality Assurance: Routinely evaluated by Western Blot on Jurkat lysates.Western Blot Analysis: 1:500 dilution of this lot detected ENDOGLIN on 10 μg of Jurkat lysates. View All» Purification Method: Purified View All» Presentation: Purified mouse monoclonal IgG2a in 0.02M phosphate buffer, 0.25M sodium chloride, 0.1% sodium azide, pH 7.6 View All» Storage Conditions: Stable at 2-8°C for up to 1 year from date of receipt. View All» UniProt Number: P17813 View All» Entrez Gene Number: NM_000118.1 View All» Gene Symbol:
  • ENG

  • ORW

  • CD105

  • HHT1

  • END

  • FLJ41744

  • ORW1

  • endoglin
    View All» Alternate Names:
    • CD105

    • Ancillary TGF-beta Receptor
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry

      • Immunocytochemistry

      • Immunoprecipitation

      • Flow Cytometry

      • ELISA
        View All» Entrez Gene Summary: Endoglin is a homodimeric transmembrane glycoprotein highly expressed by endothelial cells. It is a component of the transforming growth factor beta receptor complex as it binds TGFB1 and TGFB3 with high affinity. Mutations in the endoglin gene produce hereditary hemorrhagic telangiectasia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. View All» UniProt Summary: FUNCTION: SwissProt: P17813 # Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors.SIZE: 658 amino acids; 70578 Da SUBUNIT: Homodimer that forms an heteromeric complex with the signaling receptors for transforming growth factor-beta: TGF-beta receptors I and/or II. It is able to bind TGF-beta 1, and 3 efficiently and TGF-beta 2 less efficiently.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Endoglin is restricted to endothelial cells in all tissues except bone marrow.DISEASE: SwissProt: P17813 # Defects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1) [MIM:187300, 108010]; also known as Osler-Rendu-Weber syndrome 1 (ORW1). HHT1 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary (PAVM), cerebral (CAVM) and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia. Although the first symptom of HHT1 in children is generally nose bleed, there is an important clinical heterogeneity. View All» Product Name: Anti-Endoglin Antibody, clone P3D1 | 05-1424 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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