货号：05-1321

品牌：Merck Millipore

规格：100Ug

目录价：￥6895.00

市场价格：￥5860.75

会员价格：￥5516.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-BMI1 Antibody, clone AF27 | 05-1321 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes BMI1. View All» Molecular Weight: ~35 kDa View All» Immunogen: MBP-tagged recombinant protein corres-ponding to full length human BMI1. View All» Clone: AF27 View All» Isotype: IgG1κ View All» Background Information: The BMI1 protein is a member of the polycomb group (PcG) proteins. PcG proteins form multiprotein complexes that function as transcriptional repressors. Several lines of evidence implicate BMI1 in tumorigenesis. BMI1 cooperates with c-Myc in the generation of lymphomas in double transgenic mice. BMI1 blocks senescence and immortalizes mouse embryo fibroblasts, although not human fibroblasts, and in combination with an activated H-ras gene, leads to neoplastic transformation. The BMI1 gene is amplified in certain mantle cell lymphomas and is overexpressed in a subset of non-small cell lung cancer, colorectal carcinomas, multiple myelomas and medulloblastomas, but not glioblastomas. The transformation of human hematopoietic progenitor cells by the oncogenic fusion protein E2a-Pbx1 requires BMI1. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Application Notes: Chromatin Immunoprecipitation (ChIP): A previous lot was used by an independent laboratory in ChIP. (Bracken, A.P., et al., 2007). View All» Control: MEF1 cell lysate View All» Quality Assurance: Evaluated by Immunoprecipitation in MEF1 cell lysate.Immunoprecipitation Analysis: 10 μg/mL of this antibody immunoprecipitated BMI1 from 100 μg of MEF1 cell lysate. View All» Purification Method: Anti-BMI1, clone AF27 View All» Presentation: Purified mouse monoclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable at 2-8°C for 1 year from date of receipt. View All» UniProt Number: P35226 View All» Entrez Gene Number: NP_005171 View All» Gene Symbol:

• MGC12685

• PCGF4

• RNF51

• flvi-2/bmi-1
  View All» Alternate Names:
  • B lymphoma Mo-MLV insertion region 1 homolog

  • B lymphoma Mo-MLV insertion region 1 homolog (mouse)

  • BMI1 polycomb ring finger oncogene

  • Polycomb group RING finger protein 4

  • RING finger protein 51

  • murine leukemia viral (bmi-1) oncogene homolog

  • oncogene BMI-1

  • polycomb group protein Bmi1

  • polycomb group ring finger 4
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunoprecipitation View All» UniProt Summary: FUNCTION: Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2. SUBUNIT STRUCTURE: Component of chromatin-associated class II polycomb repressive complex 1 (PRC1/hPRC-H) at least composed of PCGF2/RNF110, BMI1/PCGF4, CBX2/M33, CBX4/PC2, CBX8/PC3, PHC1, PHC2, PHC3, SCMH1, RING1 and RNF2/RING2. Also component of E3 ubiquitin ligase complex or human polycomb repressive complex 1-like at least composed of PHC2, BMI1, RING1 and RNF2. Interacts with SPOP. Part of a complex consisting of BMI1, CUL3 and SPOP. Interacts with E4F1. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. PTM: May be polyubiquitinated; which does not lead to proteasomal degradation.INVOLVEMENT IN DISEASE: Cooperates with the MYC oncogene to produce B-lymphomas.SEQUENCE SIMILARITIES: Contains 1 RING-type zinc finger. View All» Product Name: Anti-BMI1, clone AF27 View All» Concentration: AF27 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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