货号：05-1244

品牌：Merck Millipore

规格：

目录价：￥4739.00

市场价格：￥4028.15

会员价格：￥3791.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-O-GlcNAc Antibody, clone 18B10.C7(3) | 05-1244 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes O-GluNAc. View All» Molecular Weight: Various View All» Epitope: N/A View All» Immunogen: SANM-conjugated linear peptide corresponding to human O-GluNAc. View All» Clone: 18B10.C7 View All» Isotype: IgG1κ View All» Background Information: O-linked N-acetylglucosamine (O-GlcNAc), is a member of the O-GlcNAc transferase family. O-GlcNAc is a posttranslational modification characterized by the attachment of N-acetylglucosamine to specific serine/threonine hydroxyl groups. It plays an important role in nutrient sensing, gene expression, and protein degradation. O-GlcNAc is widely expressed in the pancreas and is present in smaller amounts in skeletal muscle, heart, brain and placenta. View All» Species Reactivity: Human View All» Species Reactivity Note: Proven to react with human. View All» Control: HEK293 cell lysate View All» Quality Assurance: Evaluated by Western Blot in O-GlcNAc transferease transfected HEK293 cell lysate and O-GlcNAcase transfected transfected HEK293 cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected O-GlcNAc on 10 µg O-GlcNAc transferease transfected HEK293 cell lysate and O-GlcNAcase transfected transfected HEK293 cell lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O15294 View All» Entrez Gene Number: NP_858058.1 View All» Gene Symbol:

• OGT

• HRNT1

• O-GLCNAC
  View All» Alternate Names:
  • O-GlcNAc transferase p110 subunit

  • O-GlcNAc transferase subunit p110

  • O-linked GlcNAc transferase

  • O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)

  • O-linked N-acetylglucosamine transferase 110 kDa subunit

  • uridinediphospho-N-acetylglucosamine:polypeptidebeta-N-acetylglucosaminyl transferase
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT) catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains nine tetratricopeptide repeats and a putative bipartite nuclear localization signal. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq] View All» UniProt Summary: FUNCITON: Addition of nucleotide-activated sugars directly onto the polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine. Mediates the O-glycosylation of MLL5.CATALYTIC ACTIVITY: UDP-N-acetyl-D-glucosamine + peptide = UDP + N-acetyl-beta-D-glucosaminyl-peptide.Pathway Protein modification; protein glycosylation.SUBUNIT STRUCTURE: Heterotrimer of two 110 kDa and one 70 kDa subunits. It is not known if the 70 kDa subunit is encoded by a separate gene or is the product of either of a proteolytic degradation or an alternative initiation of the 110 kDa subunit By similarity. Component of the MLL5-L complex, at least composed of MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT. Interacts with HCFC1.SUBCELLULAR LOCATION: Cytoplasm Potential. Nucleus Potential. TISSUE SPECIFICTY: Highly expressed in pancreas and to a lesser extent in skeletal muscle, heart, brain and placenta. Present in trace amounts in lung and liver.SEQUENCE SIMILARITIES: Belongs to the O-GlcNAc transferase family.Contains 13 TPR repeats. View All» Product Name: Anti-O-GlcNAc, clone 18B10.C7(3) View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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