货号：05-118

品牌：Merck Millipore

规格：500Ug

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-FGF-2/basic FGF Antibody, clone bFM-2 | 05-118 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Product Overview: This antibody can cross-react with native and heat-inactivated basic FGF but will not neutralize biological activity. Upstate recommends anti-FGF-2/basic FGF, neutralizing (Catalog #05-117) for neutralizing activity. View All» Specificity: This antibody detects FGF-2/basic FGF. View All» Molecular Weight: 17.5 kDa View All» Immunogen: Purified bovine brain basic FGF (FGF-2, HBGF-2). Clone bFM-2. View All» Clone: bFM-2 View All» Isotype: IgG1κ View All» Background Information: FGF basic (FGF2) is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. FGF2 is involved in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. FGF2 mRNA contains multiple polyadenylation sites, and is alternatively translated from AUG and non-AUG (CUG) initiation codons resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. View All» Species Reactivity:

• Human

• Bovine

• Mouse

• Rat
  View All» Species Reactivity Note: This antibody is highly specific for basic FGF from bovine, human, rat, and mouse sources and does not cross-react with bovine acidic FGF (FGF-1, HBGF-1).Important Note: This antibody can cross-react with native and heat-inactivated basic FGF but will not neutralize biological activity (Uteza, Y., 1999). Upstate recommends anti-FGF-2/basic FGF, clone bFM-1 (neutralizing) (Catalog # 05-117) for neutralizing activity. View All» Application Notes: Immunohistochemistry: Previous lots of this antibody have been shown to immunostain frozen brain sections fixed with ice-cold, ethanol:acetic acid [95:5]. This antibody has also been used at 10 μg/mL to stain paraffin-embedded sections (Matsuzaki, K., 1989). View All» Control: Fetal liver or kidney tissue. View All» Quality Assurance: Evaluated on basic FGF (Catalog #01-114).Western Blot Analysis: 0.5-2 μg/mL of this antibody detected 100 ng FGF-2/basic FGF, carrier-free (Catalog # 01-114). View All» Purification Method: Ammonium sulfate precipitation and DEAE-cellulose chromatography View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing PBS, pH 7.4, purified by ammonium sulfate precipitation and DEAE Sephacryl chromatography. Frozen solution. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt. View All» UniProt Number: P09038 View All» Entrez Gene Number: NM_002006.3 View All» Gene Symbol:
  • FGF2

  • Prostatropin

  • BFGF

  • prostatropin

  • HBGF-2

  • FGFB
    View All» Alternate Names:
    • Basic fibroblast growth factor

    • basic fibroblast growth factor bFGF

    • fibroblast growth factor 2

    • fibroblast growth factor 2 (basic)

    • heparin-binding growth factor 2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunohistochemistry

      • Radioimmunoassay

      • Western Blotting
        View All» Entrez Gene Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. View All» UniProt Summary: FUNCTION: SwissProt: P09038 # The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors.SIZE: 155 amino acids; 17254 Da SUBUNIT: Monomer. Interacts with CSPG4 and FGFBP1. Found in a complex with FGFBP1, FGF1 and FGF2.SIMILARITY: SwissProt: P09038 ## Belongs to the heparin-binding growth factors family. MISCELLANEOUS: This protein binds heparin more strongly than does aFGF. View All» Brand Family: Upstate View All» Product Name: Anti-FGF-2/basic FGF Antibody, clone bFM-2 | 05-118 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 500 μg View All» Format: Purified View All» Host: Mouse View All»
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