货号：05-117

品牌：Merck Millipore

规格：500Ug

目录价：￥5570.00

市场价格：￥4734.50

会员价格：￥4456.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-FGF-2/basic FGF (neutralizing) Antibody, clone bFM-1 | 05-117 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: This antibody recognizes the non-denatured form of FGF-2/basic FGF; does not cross-react with bovine acidic FGF. View All» Molecular Weight: 17.5 kDa View All» Epitope: a.a. 5-24 View All» Immunogen: Purified bovine brain basic FGF (HBGF-2). Clone bFM-1. View All» Clone: bFM-1 View All» Isotype: IgG1κ View All» Background Information: Basic fibroblast growth factor, also known as bFGF or FGF2, is a member of the fibroblast growth factor family.In normal tissue, basic fibroblast growth factor is present in basement membranes and in the subendothelial extracellular matrix of blood vessels. It stays membrane-bound as long as there is no signal peptide.It has been hypothesized that, during both wound healing of normal tissues and tumor development, the action of heparan sulfate-degrading enzymes activates bFGF, thus mediating the formation of new blood vessels, a process known as angiogenesis.Additionally, bFGF is a critical component of human embryonic stem cell culture medium; the growth factor is necessary for the cells to remain in an undifferentiated state, although the mechanisms by which it does this are poorly defined. View All» Species Reactivity:

• Bovine

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: This antibody is highly specific for the non-denatured form of FGF-2/basic FGF from bovine, human, rat and mouse sources. Does not cross-react with bovine acidic FGF. View All» Applications Not Recommended: Western Blotting View All» Control: Fetal liver or kidney tissue. View All» Quality Assurance: Routinely evaluated by neutralization of greater than 50% of growth of FBHE cells simulated with FGF-2/bFGF.Neutralization of bFGF Activity Assay: 2.5 µg/mL of this lot of antibody neutralized greater than 40% of growth of FBHE cells simulated with 5 ng/mL of FGF-2/bFGF. View All» Purification Method: Ammonium sulfate precipitation and DEAE-cellulose chromatography View All» Presentation: Purified mouse monoclonal IgG1κ in TBS. Protein determined by a Bradford microtiter assay using mouse IgG as the standard. Frozen solution. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt. Aliquot to avoid repeated freezing and thawing. For maximum recovery of the product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: P09038 View All» Entrez Gene Number: NM_002006.3 View All» Gene Symbol:
  • FGF2

  • Prostatropin

  • BFGF

  • prostatropin

  • HBGF-2

  • FGFB
    View All» Alternate Names:
    • Basic fibroblast growth factor

    • basic fibroblast growth factor bFGF

    • fibroblast growth factor 2

    • fibroblast growth factor 2 (basic)

    • heparin-binding growth factor 2.
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Neutralizing

      • Radioimmunoassay
        View All» Entrez Gene Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. View All» UniProt Summary: FUNCTION: SwissProt: P09038 # The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors.SIZE: 155 amino acids; 17254 Da SUBUNIT: Monomer. Interacts with CSPG4 and FGFBP1. Found in a complex with FGFBP1, FGF1 and FGF2.SIMILARITY: SwissProt: P09038 ## Belongs to the heparin-binding growth factors family. MISCELLANEOUS: This protein binds heparin more strongly than does aFGF. ... hide » see more » View All» Brand Family: Upstate View All» Product Name: Anti-FGF-2/basic FGF (neutralizing) Antibody, clone bFM-1 | 05-117 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 500 µg View All» Format: Purified View All» Host: Mouse View All»
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        © Merck Millipore代理05-117 Anti-FGF-2/basic FGF (neutralizing) Antibody, clone bFM-1;抗-FGF-2/碱性FGF（中和）抗体，克隆bFM-1store at -20℃，产品报价联系微信jinshanbio