货号：05-1100X

品牌：Merck Millipore

规格：30UL

目录价：￥3057.00

市场价格：￥2598.45

会员价格：￥2445.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Sulfotyrosine Antibody, Clone Sulfo-1C-A2 | 05-1100X View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes sulfated tyrosine residues on various proteins. Does not recognize phosphotyrosine or unmodified tyrosines. View All» Molecular Weight: n/a View All» Epitope: Sulfated Tyrosine View All» Immunogen: This antibody was developed using a phage display library as described in Kehoe et al., 2006. The selection antigens were KAKISDP-DY(SO3)MTGYMDAC and KDKKYATEY(SO3)-EYLDYDFC View All» Clone: Sulfo-1C-A2 View All» Isotype: IgG2aκ View All» Background Information: Sulfotyrosine is a common post-translational modification of secretory, plasma membrane, and lysosomal proteins. The sulfation reaction is catalyzed by specific sulfotransferase enzymes in the trans-Golgi-network. Tyrosine sulfation occurs in all multicellular organisms and up to 1% of the tyrosines in the total protein content of a cell can be sulfated. Sulfotyrosines mediates many receptor-ligand binding interactions, including the interaction of P-selectin glycoprotein ligand-1 with P-selectin, factor VIII binding to von Willebrand factor, and interactions between thrombin and hirudin. Sulfotyrosine is also involved in the entry of several parasites and viruses; for example, tyrosine sulfation of the HIV-1 co-receptor CCR5 is required for viral entry into host cells, and tyrosine sulfation of the Duffy antigen/receptor for chemokines is crucial for erythrocyte invasion by the malaria parasite Plasmodium vivax. This clone was derived from the antibody described in Kehoe et al., 2006. View All» Species Reactivity: All View All» Species Reactivity Note: Broad species reactivity. Tested using human, mouse, bovine, and porcine, but the antibody is predicted to recognize any sulfotyrosine, regardless of surrounding amino acid sequence. View All» Application Notes: WB, IP, ELISA View All» Quality Assurance: Assayed using sulfatase treated bovine fibrinogen vs. untreated fibrinogen. View All» Purification Method: Culture supernatant, purified by protein G affinity chromatography View All» Presentation: 100 μl in 100 mM Tris, 150 mM NaCl, 180 mM Glycine, pH 7.5 containing 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year from date of receipt when stored at +2-8°C. View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:

• Western Blotting

• Immunoprecipitation

• ELISA
  View All» Brand Family: Upstate View All» Product Name: Anti-Sulfotyrosine View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 30 μL View All» Format: Purified View All» Host: Mouse View All»
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