货号：MAB5676

品牌：Merck Millipore

规格：EA

目录价：￥4164.00

市场价格：￥3539.40

会员价格：￥3331.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-ACE2 Antibody | MAB5676 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: ACE2 [Angiotensin-converting enzyme 2, SARS receptor]. View All» Molecular Weight: 90 kDa View All» Immunogen: Recombinant human ACE2. View All» Isotype: IgG1 View All» Species Reactivity: Human View All» Application Notes: Western blot: 1:2,000-1:10,000 using ECL. Reacts with the ~90 kDa ACE2 protein. Suggested blocking and dilution buffer is PBST with 0.05% Tween 20 with 5% skim milk. Suggested incubation time is 1 hour at room temperature. ELISA, direct and indirect: 1:2,000-1:10,000. Optimal working dilutions must be determined by the end user. View All» Presentation: Liquid in PBS, pH 7.4. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q9BYF1 View All» Entrez Gene Number: NM_021804.1 View All» Gene Symbol:

• ACE2

• DKFZP434A014

• ACEH

• ORFNames=UNQ868/PRO1885

• EC 3.4.17.- [Contains: Processed angiotensin-converting enzyme 2].
  View All» Alternate Names: Angiotensin-converting enzyme 2, SARS receptor View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Western Blotting
    View All» Entrez Gene Summary: The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This protein catalyzes the cleavage of angiotensin I into angiotensin 1-9. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. View All» UniProt Summary: FUNCTION: SwissProt: Q9BYF1 # Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin- 13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.COFACTOR: Binds 1 zinc ion per subunit. & Binds 1 chloride ion per subunit.SIZE: 805 amino acids; 92463 Da SUBUNIT: Interacts with ITGB1. Interacts with SARS-CoV and HCoV- NL63 spike glycoprotein.SUBCELLULAR LOCATION: Processed angiotensin-converting enzyme 2: Secreted. & Cell membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells (at protein level). Expressed in heart, kidney, testis, and gastrointestinal system.PTM: N-glycosylation on Asn-90 may limit SARS infectivity.SIMILARITY: SwissProt: Q9BYF1 ## Belongs to the peptidase M2 family. View All» Brand Family: Chemicon View All» Product Name: Anti-ACE2 Antibody | MAB5676 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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