货号：MAB5634

品牌：Merck Millipore

规格：

目录价：￥3990.00

市场价格：￥3391.50

会员价格：￥3192.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Spastin Antibody, clone Sp3G11/1 | MAB5634 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Cat. # MAB5634 recognizes Spastin. View All» Molecular Weight: 52 kDa View All» Immunogen: Full length recombinant protein View All» Clone: Sp3G11/1 View All» Isotype: IgG2aκ View All» Background Information: Spastin is a distinct microtubule-severing protein. Autosomal dominant mutations in the SPG4 locus corresponding to spastin are the most common cause of hereditary spastic paraplegia (HSP), a neurodegenerative disease that afflicts the adult corticospinal tracts. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Human, Mouse and Rat. Reactivity with other species has not been tested. View All» Application Notes: Immunohistochemistry: Cat. # MAB5634 can detect Spastin in paraffin sections of human brain at 1:25 dilutions View All» Control: HeLa cell lysate View All» Quality Assurance: Routinely evaluated by Western Blot on HeLa cell lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3 View All» Storage Conditions: Maintain at 2-8°C for up to 1 year from date of receipt. View All» UniProt Number: Q9UBP0 View All» Entrez Gene Number: Q9UBP0 View All» Gene Symbol:
  • ADPSP

  • FSP2

  • KIAA1083

  • OTTHUMP00000158570

  • SPG4

  • spastin
    View All» Alternate Names: spastic paraplegia 4 (autosomal dominant; spastin) View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry (Paraffin)
      View All» Entrez Gene Summary: This gene encodes a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. The encoded ATPase may be involved in the assembly or function of nuclear protein complexes. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their full length sequences have not been determined. Mutations associated with this gene cause the most frequent form of autosomal dominant spastic paraplegia 4. [provided by RefSeq] View All» UniProt Summary: FUNCTION: Probable ATPase involved in the assembly or function of nuclear protein complexes. May also be involved in some aspects of microtubule dynamics. SUBUNIT: Interacts directly with CHMT1B and ZFYVE27. SUBCELLULAR LOCATION: Nucleus. Cytoplasm, perinuclear region. ALTERNATIVE PRODUCTS: 2 named isoforms [FASTA] produced by alternative splicing. Name 1 Isoform ID Q9UBP0-1 This is the isoform sequence displayed in this entry. TISSUE SPECIFICITY: Ubiquitous. DISEASE: Defects in SPAST are the cause of spastic paraplegia autosomal dominant type 4 (SPG4) [MIM:182601]. Spastic paraplegia is a degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. SPG4 is the most common form of autosomal dominant spastic paraplegias. SIMILARITY: Belongs to the AAA ATPase family. SIMILARITY: Contains 1 MIT domain. View All» Product Name: Anti-Spastin Antibody, clone Sp3G11/1 | MAB5634 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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