货号：04-973

品牌：Merck Millipore

规格：100Ug

目录价：￥4438.00

市场价格：￥3772.30

会员价格：￥3550.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-CD39 Antibody, clone 5F2 | 04-973 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes CD39. View All» Molecular Weight: ~ 100 kDa. It has been published that CD39 shows molecular weights between ~70-100 kDa (Wang, T.F. et al., 1996). View All» Epitope: Unknown View All» Immunogen: Recombinant protein corresponding to mouse CD39. View All» Clone: 5F2 View All» Isotype: IgG1κ View All» Background Information: Ectonucleoside triphosphate diphosphohydrolase 1 (NTDase 1 or CD39) belongs to the membrane-bound ecto-nucleoside triphosphates diphosphohydrolase family (E-NTPDases) that are characterized for their ability to hydrolyze nucleoside di- and triphosphates, such as ATP, in the presence of cations, i.e. CA2+ and Mg2+. CD39 is an important membrane protein containing two transmembrane domains and a large NTPDase active, extracellular region containing apyrase conserved regions. It is heavily glycosolated, having six known N-glycosolation sites, and functions on the plasma membrane’s outer surface. CD39 initiates the metabolism, of ATP and ADP to adenosine through a 2-step exzymatic reaction, providing extracellular adenosine for the purpose of regulating various inflammatory endpoints. It is a putative marker for B-cell activation and its expression has also been observed on NK-cells, dendritic cells, T-cells, and vascular endothelial cells. CD39 is a known inhibitor of ADP-induced platelet aggregation and may also play a role in angiogenesis. View All» Species Reactivity: Mouse View All» Species Reactivity Note: Demonstrated to react with mouse. View All» Application Notes: Western Blot Analysis: A previous lot was used by an independent laboratory in WB. View All» Control: BALB/c splenocytes View All» Quality Assurance: Evaluated by Flow Cytometry in BALB/c splenocytes.Flow Cytometry Analysis: 0.1 µg/mL of this antibody detected CD39 in BALB/c splenocytes. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P55772 View All» Entrez Gene Number: NP_033978 View All» Gene Symbol:

• CD39

• Ecto-apyrase

• Ectoapyrase
  View All» Alternate Names:
  • ectonucleoside triphosphate diphosphohydrolase 1

  • ATPDase

  • ecto-apyrase

  • NTPDase-1

  • Ecto-ATP diphosphohydrolase

  • Lymphoid cell activation antigen

  • NTPDase 1

  • Ecto-apyrase

  • CD39 antigen
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Flow Cytometry

    • Western Blotting
      View All» UniProt Summary: FUNCTION: In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation. Hydrolyzes ATP and ADP equally well.CATALYTIC ACTIVITY: ATP + 2 H2O = AMP + 2 phosphate.COFACTOR: Calcium (By similarity).MAGNESIUM: (By similarity).SUBUNIT STRUCTURE: Homodimer; disulfide-linked (By similarity).SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential). SEQUENCE SIMILARITIES: Belongs to the GDA1/CD39 NTPase family. View All» Product Name: Anti-CD39, clone 5F2 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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