货号：MAB5592

品牌：Merck Millipore

规格：

目录价：￥5215.00

市场价格：￥4432.75

会员价格：￥4172.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Nerve Growth Factor Receptor Antibody, clone MLR2 | MAB5592 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Nerve Growth Factor Receptor (NGF Receptor p75). View All» Immunogen: Human p75 coupled to an Fc fragment. View All» Clone: MLR2 View All» Isotype: IgG2a View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Application Notes: Immunohistochemistry on motor neurons in spinal cord with lesioned siatic nerve: 1-2 μg/mL. Suggested fixative is 4% formaldehyde. The antibody has not yet been tested on paraffin embedded tissue. Optimal working dilutions must be determined by end user. View All» Control: Brain tissue View All» Purification Method: Protein A purfied View All» Presentation: Purified immunoglobulin. Lyophilized. Contains no preservative. Reconstitute with 100 μL of sterile distilled water. View All» Storage Conditions: Maintain lyophilized material at -20°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C to -70°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. Glycerol (ASC grade or better) can be added (1:1) for additional stability. View All» UniProt Number: P08138 View All» Entrez Gene Number: NM_002507 View All» Gene Symbol:
  • NGFR

  • Gp80-LNGFR

  • CD271

  • p75(NTR)

  • TNFRSF16
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunohistochemistry View All» Entrez Gene Summary: Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. View All» UniProt Summary: FUNCTION: SwissProt: P08138 # Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.SIZE: 427 amino acids; 45183 Da SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR- associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.DOMAIN: SwissProt: P08138 Death domain is responsible for interaction with RANBP9.PTM: N- and O-glycosylated. & O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc. & Phosphorylated on serine residues.SIMILARITY: Contains 1 death domain. & Contains 4 TNFR-Cys repeats. View All» Brand Family: Chemicon View All» Product Name: Anti-Nerve Growth Factor Receptor Antibody, clone MLR2 | MAB5592 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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