货号：04-932

品牌：Merck Millipore

规格：100Ul

目录价：￥6588.00

市场价格：￥5599.80

会员价格：￥5270.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Calmodulin Binding Protein Epitope Tag Antibody, clone C16T | 04-932 View All» Replaces: 05-932 View All» Promotional Text: Special Offer on Antibodies! Click Here! View All» Specificity: Recombinant proteins containing the calmodulin binding protein epitope tag. View All» Molecular Weight: The molecular weight is related to the tagged protein. View All» Epitope: CBP epitope View All» Immunogen: KLH-conjugated, synthetic peptide corresponding to the Calmodulin Binding Protein (CBP) epitope tag found in several E. coli expression vectors. View All» Clone: C16T View All» Isotype: IgG View All» Background Information: Calmodulin Binding Protein (CBP) epitope tags are found in several E. coli expression vectors. Calmodulin (CaM), a small 17 kDa ubiquitous Ca2+ binding protein, acts as an intracellular Ca2+ receptor and transduces Ca2+ transients, usually in response to growth factors. It mediates the activity of a number of Ca2+ regulating enzymes, including protein kinases, phosphatases, nitric oxide synthases, and phosphodiesterase. Calmodulin is the principal intracellular calcium receptor. It is an acidic protein of 148 residues, and upon binding Ca2+, it in turn binds to short peptide sequences of many target proteins. Such interaction is thought to induce a conformational change on the target, resulting in its activation. Targets include the constitutively expressed nitric oxide synthases, the CaM kinases, and PP2B/Calcineurin. View All» Species Reactivity: Vertebrates View All» Species Reactivity Note: Vertebrates. View All» Control: Samples containing the calmodulin binding protein epitope tag. View All» Quality Assurance: Evaluated by Western Blot on lysates from transformed E. coli.Western Blot Analysis: 1:2,000 dilution of this antibody detected a recombinant protein containing the calmodulin binding protein epitope tag in lysates from transformed E. coli. View All» Presentation: Cultured supernatant with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: P62158 View All» Gene Symbol:

• CALM

• CALML2

• CAM

• CAM1

• CAM2

• CAM3

• CAMB

• CAMC

• CAMI

• CAMIII

• CaM

• DD132

• PHKD
  View All» Alternate Names:
  • calmodulin 1

  • calmodulin 1 (phosphorylase kinase, delta)

  • phosphorylase kinase, delta subunit
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Calmodulin is the archetype of the family of calcium-modulated proteins of which nearly 20 members have been found. They are identified by their occurrence in the cytosol or on membranes facing the cytosol and by a high affinity for calcium. Calmodulin contains 149 amino acids and has 4calcium-binding domains. Its functions include roles in growth and the cell cycle as well as in signal transduction and the synthesis and release of neurotransmitters.[supplied by OMIM] View All» UniProt Summary: FUNCTION: Calmodulin mediates the control of a large number of enzymes and other proteins by Ca2+. Among the enzymes to be stimulated by the calmodulin-Ca2+ complex are a number of protein kinases and phosphatases. Together with CEP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.SUBUNIT STRUCTURE: Interacts with MYO1C and RRAD By similarity. Interacts with CEP97, CEP110, TTN/titin and SRY.SUBCELLULAR LOCATION: Cytoplasm › cytoskeleton › spindle. Cytoplasm › cytoskeleton › spindle pole. Note: Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules.PTM: Ubiquitination results in a strongly decreased activity By similarity.Phosphorylation results in a decreased activity By similarity.MISCELLANEOUS: This protein has four functional calcium-binding sites.SEQUENCE SIMILARITIES: Belongs to the calmodulin family.Contains 4 EF-hand domains. View All» Product Name: Anti-Calmodulin Binding Protein Epitope Tag, clone C16T View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μl View All» Host: Rabbit View All»
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