货号：04-903

品牌：Merck Millipore

规格：100Ul

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-GSK3α/β Antibody | 04-903 View All» Replaces: 05-903 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: GSK3 alpha and beta. View All» Molecular Weight: ~46 kDa (beta) and 51 kDa (alpha) View All» Immunogen: N-terminal 6His-tagged recombinant full length human GSK3β. View All» Isotype: IgG View All» Background Information: Glycogen Synthase Kinase 3 differs from most serine/threonine kinases in that it is active in the absence of the action of signaling pathways. Two isoforms exist, GSK3α and GSK3β. The function of GSK3 is to phosphorylate Glycogen Synthase and thereby inactivate it. Insulin action stimulates the PI3 Kinase pathway, resulting in Akt activation, which phosphorylates and inactivates GSK3. Glycogen Synthase is then rapidly dephosphorylated and activated. Other GSK3 substrates include Jun (on inhibitory sites), and eIF2B. Phosphorylation of Tau by GSK3 may relate to development of Alzheimer's disease. Phosphorylation state-specific antibodies directed against the Akt site (Ser21) on GSK3 are suitable for surrogate assays of the activation state of the pathway. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Human and mouse.Predicted to cross-react with rat based on sequence homology. View All» Application Notes: Immunoprecipitation: 2-8 μL of a previous lot of antibody immunoprecipitated GSK3 alpha and beta from 100 μg of HEK293 RIPA lysate. NOTE: This antibody also successfully immunoprecipitated GSK3 alpha and beta using the Catch and Release® v2.0 Reversible Immunoprecipitation System (Catalog # 17-500). View All» Control: HEK293 cell lysate View All» Quality Assurance: Evaluated by western blot on lysates from HEK293 cells.Western Blotting Analysis: A 1:1,000 dilution of this antibody detected GSK3 alpha and GSK3 beta in RIPA lysates from A431, HEK293, Jurkat, HeLa NE or 3T3/A31 cells. View All» Presentation: Cultured supernantant containing 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: P49840 View All» Entrez Gene Number: NP_063937.2, NP_002084.2 View All» Gene Symbol:
  • DKFZp686D0638

  • EC 2.7.11.26
    View All» Alternate Names:
    • GSK-3 alpha

    • glycogen synthase kinase 3 alpha
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunoprecipitation
        View All» Entrez Gene Summary: Glycogen synthase kinase 3-alpha (GSK3A; EC {2.7.1.37}) is a multifunctional protein serine kinase,homologous to Drosophila 'shaggy' (zeste-white3) and implicated in the control ofseveral regulatory proteins including glycogen synthase (see GYS1, {138570}) and transcriptionfactors (e.g., JUN, {165160}). It also plays a role in the WNT ({164820}) and PI3K (see PIK3CG, {601232}) signaling pathways (see review by {1:Ali et al. (2001) View All» UniProt Summary: FUNCTION:Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN By similarity.CATALYTIC ACTIVITY: ATP + [tau protein] = ADP + [tau protein] phosphate.SUBUNIT STRUCTURE:Monomer By similarity.SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.Contains 1 protein kinase domain. View All» Product Name: Anti-GSK3α/β View All» Concentration: Cultured supernantant containing 0.05% sodium azide. View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μl View All» Format: Culture Supernatant View All» Host: Rabbit View All»
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