货号：04-856

品牌：Merck Millipore

规格：100UL

目录价：￥4438.00

市场价格：￥3772.30

会员价格：￥3550.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-TBK1 Antibody, clone AOW9 | 04-856 View All» Replaces: 05-856 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: TBK1; Does not cross-react with IKKε, IKKα or IKKβ. View All» Molecular Weight: 85 kDa View All» Epitope: a.a. 642-645 View All» Immunogen: Peptide corresponding to the sequence C...EEVS... (amino acids 642-645) of human TANK-binding kinase 1 (TBK1) with an N-terminal cysteine added for conjugation purposes. View All» Clone: AOW9 View All» Isotype: IgG View All» Background Information: TBK, also known as IκB kinase (IKK)-related kinase NAK, belong to the serine/threonine IKK kinase family and is thought to play a role in NF-kappa-B (NF-κB) activation. The NF-κB complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NF-κB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NF-κB activation in response to certain growth factors. For example, the protein can form a complex with the IKB protein TANK and TRAF2 and release the NF-κB inhibition caused by TANK. View All» Species Reactivity:

• Human

• Mouse

• Canine

• Chicken
  View All» Species Reactivity Note: Human. Predicted to cross-react with mouse, dog, and chicken based on sequence homology. View All» Application Notes: Immunoprecipitation: 1-4 μL of a previous lot immunoprecipitated TBK1 from 100 μg of HEK293 RIPA lysate. View All» Control: RIPA lysates from HEK293 cells. View All» Quality Assurance: Evaluated by western blot on RIPA lysates from HEK293 cells.Western Blot Analysis: A 1:500 to 1:2,000 of this antibody detected TBK1 in RIPA lysates from HEK293 cells. View All» Presentation: Cultured supernatant containing 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: Q9UHD2 View All» Entrez Gene Number: NP_037386 View All» Gene Symbol:
  • EC 2.7.11.1

  • FLJ11330

  • NAK

  • T2K
    View All» Alternate Names:
    • NF-kB-activating kinase

    • NF-kappa-B-activating kinase

    • TANK-binding kinase 1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunoprecipitation
        View All» Entrez Gene Summary: The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. For example, the protein can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK. [provided by RefSeq] View All» UniProt Summary: FUNCTION: Serine/threonine protein involved in the signaling cascade converging to the activation of the transcription factor NF-kappa-B. May function as an IKK kinase, playing an essential role in the transcription of a subset of TNF-alpha-induced genes. Also mediates production of RANTES/CCL5 and interferon-beta/IFNB1. Has a pivotal role in the innate immune response. Phosphorylates Borna disease virus (BDV) P protein. Phosphorylates and activates IRF3 and IRF7 and allows their nuclear localization. This leads to production of alpha/beta interferons and the development of a cellular antiviral state. It also seems to be a central factor in the induction of the antiviral interferon response. Inhibition of its interaction with IRF3, due to HCV NS3 binding or BDV P protein seems to be one mechanism of inhibition of the innate immune responses of hepatitis C virus (HCV) infection or Borna disease virus infection respectively. Ref.1 Ref.2 Ref.5 Ref.7 Ref.8 Ref.11Catalytic activity ATP + a protein = ADP + a phosphoprotein.SUBUNIT: Interacts with TIRAP, TANK and TRAF2. Part of a ternary complex consisting of TANK, TRAF2 and TBK1. Interacts with AZI2. Interacts with SIKE. Interacts with TICAM1/TRIF, IRF3 and DDX58/RIG-I, interactions are disrupted by the interaction between TBK1 and SIKE. Interacts with HCV NS3, a hepatitis C virus protein and with BDV P protein, a Borna disease virus protein. Ref.1 Ref.6 Ref.9 Ref.10 Ref.12 Ref.13 Ref.14SUBCELLULAR LOCATION:Cytoplasm. Ref.11SPECIFICITY:Ubiquitous with higher expression in testis. Ref.2SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.Contains 1 protein kinase domain. View All» Product Name: Anti-TBK1, clone AOW9 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μL View All» Format: Culture Supernatant View All» Host: Rabbit View All»
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