货号：04-820

品牌：Merck Millipore

规格：100Ul

目录价：￥5062.00

市场价格：￥4302.70

会员价格：￥4049.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Estrogen Receptor α Antibody, clone 60C | 04-820 View All» Replaces: 04-820 is a recommended replacement for 05-820 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Recognizes Estrogen Receptor α. No cross-reactivity with Estrogen Receptor β. View All» Molecular Weight: 66 kDa View All» Epitope: N-term View All» Immunogen: KLH-conjugated, synthetic peptide corresponding to amino acids 13-32 (C-ALLHQIQGNELEPLNRPQLK) of human Estrogen Receptor α. The immunizing sequence is identical in rat and mouse and has 19/20 identical amino acids in bovine and porcine. View All» Clone: 60C View All» Isotype: IgG View All» Background Information: The Estrogen Receptors (ER) belong to the nuclear receptor family that contains a ligand-binding domain that maintains the protein in an inactive conformation unless bound to the hormone. Two ERs are known, ERα, classically known as ER, and ERβ, described long after ERα. Activated Estrogen Receptor is a DNA-binding protein capable of inducing many changes in gene expression. The Estrogen Receptor is believed to play an important role in the growth and development of a subset of hormone dependent human breast cancers. ERβ is expressed in prostate, ovary, and other reproductive organs. Although its steroid specificity is very similar to that of the ERα, the molecular mechanisms regulating the transcriptional activity of ERβ may be distinct from those regulating ERα. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Bovine

• Pig
  View All» Species Reactivity Note: Human. Predicted to cross-react with rat, mouse, bovine and porcine based on sequence homology. View All» Application Notes: Immunoprecipitation:4-10 μL of a previous lot of this clone immunoprecipitated Estrogen Receptor α from 1 mg of MCF-7 RIPA lysate. View All» Quality Assurance: Routinely evaluated by western blot analysis.Western Blot Analysis: This lot detected ERα at a 1:2,000 dilution in MCF-7 lysates via SDS-PAGE and transferred to PVDF (Immobilon-P). View All» Purification Method: Unpurified View All» Presentation: Cultured supernantant with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.For maximum recovery of product, centrifuge the vial prior to removing the cap. View All» UniProt Number: P03372 View All» Entrez Gene Number: NP_000116.2 View All» Gene Symbol:
  • ER

  • ER-alpha

  • ESR

  • ESRA

  • Era

  • NR3A1

  • DKFZp686N23123

  • OTTHUMP00000017718

  • OTTHUMP00000017719
    View All» Alternate Names:
    • Estradiol receptor

    • Nuclear receptor subfamily 3 group A member 1

    • estrogen receptor 1

    • estrogen receptor alpha

    • oestrogen receptor

    • steroid hormone receptor
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunoprecipitation
        View All» Entrez Gene Summary: Summary: This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breastcancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: SwissProt: P03372 # Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.SIZE: 595 amino acids; 66216 Da SUBUNIT: Binds DNA as a homodimer. Can form a heterodimer with ESR2. Interacts with NCOA3, NCOA5 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with NCOA7 in a ligand-inducible manner. Interacts with PHB2, PELP1 and UBE1C. Interacts with AKAP13. Interacts with CUEDC2. Interacts with JARID1A. Interacts with SMARD1. Interacts with SLC30A9 (By similarity). Interacts with HEXIM1 and MAP1S. Interacts with PBXIP1.SUBCELLULAR LOCATION: Nucleus.DOMAIN: SwissProt: P03372 Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.PTM: Phosphorylated by cyclin A/CDK2. Phosphorylation probably enhances transcriptional activity.SIMILARITY: Belongs to the nuclear hormone receptor family. NR3 subfamily. & Contains 1 nuclear receptor DNA-binding domain.MISCELLANEOUS: In the absence of ligand, steroid hormone receptors are thought to be weakly associated with nuclear components; hormone binding greatly increases receptor affinity. The hormone- receptor complex appears to recognize discrete DNA sequences upstream of transcriptional start sites. View All» Product Name: Anti-Estrogen Receptor α, clone 60C Antibody View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μL View All» Format: Culture Supernatant View All» Host: Rabbit View All»
        © 金山科研平台是专业的授权总代理区域代理经销平台。
        © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
        © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
        © 本文地址：https://16ao.com/thread-132049.htm
        © Merck Millipore代理04-820 Anti-Estrogen Receptor α Antibody, clone 60C, rabbit monoclonal;抗雌激素受体α抗体，克隆60C，兔单克隆store at -20℃，产品报价联系微信jinshanbio