货号：04-811

品牌：Merck Millipore

规格：100UL

目录价：￥6742.00

市场价格：￥5730.70

会员价格：￥5393.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-eNOS/NOS III (Thr495) Antibody | 04-811 View All» Replaces: Cat. # 05-811. 05-811 will only be availabe on a custom basis. View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Product Overview: Note: ADMA (Catalog #19-169) and NMMA (Catalog #19-170) are inhibitors of NOS View All» Specificity: Recognizes phosphorylated eNOS/NOS III. View All» Molecular Weight: 135 kDa View All» Immunogen: Peptide containing the sequence KK[pT]FK in which pT corresponds to phosphothreonine at residue 495 of human eNOS/NOS III View All» Modifications: Phosphorylation View All» Isotype: IgG View All» Species Reactivity: Bovine View All» Species Reactivity Note: Predicted cross-reactivity with human, rabbit, mouse and rat View All» Application Notes: Western Blot Analysis: A 1:2,000-1:10,000 dilution of this lot detected phosphorylated eNOS/NOS III in fetal bovine heart endothelial cell lysate. View All» Control: Fetal bovine heart endothelial cell lysate View All» Quality Assurance: routinely evaluated by immunoblot on fetal bovine heart endothelial cell lysate View All» Presentation: Protein A Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative. View All» Storage Conditions: Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: P29474 View All» Entrez Gene Number: NM_000603 View All» Gene Symbol:

• NOS3

• cNOS

• ECNOS

• eNOS

• EC-NOS

• NOSIII
  View All» Alternate Names:
  • NOS III

  • endothelial nitric oxidase synthase

  • endothelial nitric oxide synthase

  • nitric oxide synthase 3 (endothelial cell)
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: SwissProt: P29474 # Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. No mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.COFACTOR: Heme group. & Binds 1 FAD. & Binds 1 FMN. & Metrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme.SIZE: 1203 amino acids; 133289 Da SUBUNIT: Homodimer. Interacts with NOSIP and NOSTRIN.SUBCELLULAR LOCATION: Cell membrane, caveola. Cytoplasm, cytoskeleton. Golgi apparatus. Note=Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity.TISSUE SPECIFICITY: Platelets, placenta, liver and kidney.SIMILARITY: SwissProt: P29474 ## Belongs to the NOS family. & Contains 1 flavodoxin-like domain. View All» Brand Family: Upstate View All» Product Name: Anti-phospho-eNOS/NOS III (Thr495) View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μL View All» Format: Culture Supernatant View All» Host: Rabbit View All»
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