货号：MAB5478

品牌：Merck Millipore

规格：100UL

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Retinoid X Receptor α Antibody | MAB5478 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Reacts with Retinoid X Receptor alpha (RXRalpha). No cross reactivity with RXRbeta or RXRgamma. View All» Immunogen: Fusion protein corresponding to the DE-region of mouse RXRa. View All» Isotype: IgG1 View All» Species Reactivity:

• Human

• Mouse
  View All» Application Notes: Western blot (endogenous and recombinant protein): 1:500-1:5,000 Immunocytochemistry (transfected cells): 1:500-1:5,000 Immunoprecipitation (endogenous and recombinant protein): 1:500-1:5,000 Gel shift (endogenous and recombinant protein): 1:500-1:5,000 ELISA: 1:500-1:5,000 Optimal working dilutions must be determined by end user. View All» Presentation: Ascites fluid. Liquid. Contains no preservative. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P19793 View All» Entrez Gene Number: NM_002957.3 View All» Gene Symbol:
  • RXRA

  • FLJ16020

  • FLJ16733

  • NR2B1

  • MGC102720
    View All» Alternate Names: RXRalpha View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Electrophoretic Mobility Shift Assay

    • Immunoprecipitation

    • Western Blotting
      View All» Entrez Gene Summary: Retinoid X receptors (RXRs) and retinoic acid receptors (RARs), are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors exert their action by binding, as homodimers or heterodimers, to specific sequences in the promoters of target genes and regulating their transcription. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. View All» UniProt Summary: FUNCTION: SwissProt: P19793 # Nuclear hormone receptor. Involved in the retinoic acid response pathway. Binds 9-cis retinoic acid (9C-RA). ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer (By similarity).SIZE: 462 amino acids; 50811 Da SUBUNIT: Homodimer or forms a heterodimer with peroxisome proliferator activated receptor gamma called adipocyte-specific transcription factor ARF6. Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes (By similarity). Interacts with SFPQ. Interacts with HCV core protein. Interacts with PELP1. Interacts with SENP6.SUBCELLULAR LOCATION: Nucleus.TISSUE SPECIFICITY: Highly expressed in liver, also found in lung, kidney and heart.DOMAIN: SwissProt: P19793 Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.PTM: Sumoylated on Lys-108; which negatively regulates transcriptional activity. Desumoylated specifically by SENP6.SIMILARITY: Belongs to the nuclear hormone receptor family. NR2 subfamily. & Contains 1 nuclear receptor DNA-binding domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Retinoid X Receptor α Antibody | MAB5478 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Ascites View All» Host: Mouse View All»
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